Gene Symbol | Mapkap1 |
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Entrez Gene | 296648 |
Alt Symbol | - |
Species | Rat |
Gene Type | protein-coding |
Description | mitogen-activated protein kinase associated protein 1 |
Other Description | SAPK-interacting protein 1|TORC2 subunit MAPKAP1|mitogen-activated protein kinase 2-associated protein 1|stress-activated map kinase-interacting protein 1|target of rapamycin complex 2 subunit MAPKAP1 |
Swissprots | Q6AYF1 |
Accessions | Q6AYF1 BC079073 AAH79073 XM_006233949 XP_006234011 XM_006233950 XP_006234012 XM_008761720 XP_008759942 XM_008761721 XP_008759943 XM_008761722 XP_008759944 XM_008761723 XP_008759945 NM_001011964 NP_001011964 |
Function | Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-421'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphory |
Subcellular Location | Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Nucleus {ECO:0000250}. |
Recombinant Rat Target of rapamycin complex 2 subunit MAPKAP1(Mapkap1) - CSB-YP724513RA CSB-EP724513RA CSB-BP724513RA CSB-MP724513RA from Cusabio
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Target of rapamycin complex 2 subunit MAPKAP1 (Mapkap1), Recombinant Protein - MBS1479902 from MyBioSource
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Recombinant Rat MAPKAP1 Protein - MAPKAP1-3577R from Creative Biomart
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