PLCG1

Gene Symbol	PLCG1
Entrez Gene	5335
Alt Symbol	NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1
Species	Human
Gene Type	protein-coding
Description	phospholipase C, gamma 1
Other Description	1-phosphatidyl-D-myo-inositol-4,5-bisphosphate|1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1|PLC-148|PLC-gamma-1|inositoltrisphosphohydrolase|monophosphatidylinositol phosphodiesterase|phosphatidylinositol phospholipase C|phosphoinositidase C|phosphoinositide phospholipase C|phosphoinositide phospholipase C-gamma-1|phospholipase C, gamma 1 (formerly subtype 148)|phospholipase C-148|phospholipase C-II|phospholipase C-gamma-1|triphosphoinositide phosphodiesterase
Swissprots	E1P5W4 Q2V575 B9EGH4 B7ZLY7 P19174
Accessions	AAB70663 ABB84466 EAW75989 EAW75990 EAW75991 EAW75992 EAW75993 P19174 AB210028 BAE06110 AF147391 AK297370 BAG59815 AK309606 AL110247 CAB53696 BC136466 AAI36467 BC144136 AAI44137 BX415739 BX434193 M34667 AAA36452 XM_005260438 XP_005260495 XM_011528865 XP_011527167 XM_011528866 XP_011527168 XM_011528867 XP_011527169 XR_936550 NM_002660 NP_002651 NM_182811 NP_877963
Function	Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. {ECO:0000269|PubMed:17229814}.
Subcellular Location	Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.
Top Pathways	Epstein-Barr virus infection, MicroRNAs in cancer, Inflammatory mediator regulation of TRP channels, Choline metabolism in cancer, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® PLCγ 1 siRNA II - 6254 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® PLCγ1 siRNA I - 6293 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence® PLCgamma 1 siRNA (Human Specific) - 6421 from Cell Signaling Technology Category siRNA

PLC γ1 CRISPR/Cas9 KO Plasmid (h) - sc-400472 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PLC γ1 HDR Plasmid (h) - sc-400472-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PLC γ1 Double Nickase Plasmid (h) - sc-400472-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PLC γ1 Double Nickase Plasmid (h2) - sc-400472-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PLC γ1 CRISPR Activation Plasmid (h) - sc-400472-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PLC γ1 CRISPR Activation Plasmid (h2) - sc-400472-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PLC γ1 Lentiviral Activation Particles (h) - sc-400472-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PLC γ1 Lentiviral Activation Particles (h2) - sc-400472-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PLC γ1 siRNA (h) - sc-29452 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PLC γ1 shRNA Plasmid (h) - sc-29452-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PLC γ1 shRNA (h) Lentiviral Particles - sc-29452-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PLC-gamma 1 RNAi - H00005335-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU069301 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2105 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2105 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08679 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08679

PLCG1 siRNA (Human) - CRH3575 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PLC-gamma 1 RNAi - H00005335-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human Plcg1 (NM_002660.2) - SHH377216 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human PLCG1(NM_002660.2) - SHR120138 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human PLCG1(NM_182811.1) - SHR120540 from Creative biogene Category siRNA Species Reactivities Human

PLC γ1 CRISPR/Cas9 KO Plasmid (h2) - sc-400472-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Search more