AMFR

Gene Symbol AMFR
Entrez Gene 267
Alt Symbol GP78, RNF45
Species Human
Gene Type protein-coding
Description autocrine motility factor receptor, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase AMFR|RING finger protein 45
Swissprots P26442 Q9UKV5 Q8IZ70
Accessions AAA79361 CAH05417 EAW82857 EAW82858 Q9UKV5 AA767223 AF124145 AAD56722 AK023874 AK123962 BC017043 AAH17043 BC051032 BC056869 AAH56869 BC069197 AAH69197 BX345849 BX409690 CA748782 DQ582721 L35233 AAA79362 M63175 AAA36671 W60999 XM_005255889 XP_005255946 XM_005255890 XP_005255947 NM_001144 NP_001135 NM_138958
Function E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97- AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97- AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor. {ECO:0000269|PubMed:10456327, ECO:0000269|PubMed:11724934, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:19103148}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:11724934}; Multi-pass membrane protein {ECO:0000269|PubMed:11724934}.
Top Pathways Protein processing in endoplasmic reticulum

E3 ubiquitin-protein ligase AMFR (AMFR), Human, ELISA Kit - CSB-EL001665HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

autocrine motility factor receptor, ELISA Kit - MBS904340 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 5.86 pg/ml
Range 23.44 pg/ml-1500 pg/ml

Human E3 ubiquitin-protein ligase AMFR(AMFR) ELISA kit - CSB-EL001665HU from Cusabio

Category ELISA Kit
Sensitivity 5.8 pg/ml
Range 23.5 pg/ml-1500 pg/ml

Human GP78 / AMFR ELISA Kit (Custom ELISA) - LS-F17570 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.625-40 ng/ml

Mouse GP78 / AMFR ELISA Kit (Custom ELISA) - LS-F17571 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.625-40 ng/ml

E3 ubiquitin-protein ligase AMFR, ELISA Kit - MBS288486 from MyBioSource

Category ELISA Kit
Prices $430.00, $570.00, $2,515.00, $4,520.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

AMFR - EKH3380 from Nordic BioSite

Sensitivity 0.375ng/ml
Range 0.625-40ng/ml

AMFR ELISA Kit (Human) : 96 Wells (OKEH02407) - OKEH02407 from Aviva Systems Biology

Category ELISA Kit
Prices $480.00
Sizes 96 wells
Sensitivity < 0.34 ng/mL
Range 0.625 - 40 ng/mL

Human AMFR ELISA Kit - E004241 from Biobool

Category ELISA Kit
Sensitivity 5.86 pg/ml

Human E3 ubiquitin-protein ligase AMFR ELISA Kit - EK3532 from Signalway Antibody

Category ELISA Kit
Prices $739.00
Sizes 1x96t
Sensitivity less than 0.34ng/ml
Range 0.62-40.0 ng/mL

E3 ubiquitin-protein ligase AMFR, ELISA Kit - MBS2885000 from MyBioSource

Category ELISA Kit
Prices $430.00, $570.00, $2,515.00, $4,520.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Range 0.625-40 ng/mL

E3 ubiquitin-protein ligase AMFR, ELISA Kit - MBS762273 from MyBioSource

Category ELISA Kit
Prices $295.00, $390.00, $1,615.00, $3,015.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.375ng/ml
Range 0.625-40ng/ml

E3 ubiquitin-protein ligase AMFR, ELISA Kit - MBS9427366 from MyBioSource

Category ELISA Kit
Prices $670.00
Sizes 96 tests
Sensitivity Less than 0.34ng/mL
Range 0.62-40.0 ng/mL

Human GP78 / AMFR ELISA Kit (Competitive EIA) - LS-F39249 from LifeSpan Bioscience

Category ELISA Kit
Sensitivity 0.375
Range 0.625-40 ng/ml
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