AMFR

Gene Symbol AMFR
Entrez Gene 267
Alt Symbol GP78, RNF45
Species Human
Gene Type protein-coding
Description autocrine motility factor receptor, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase AMFR|RING finger protein 45
Swissprots P26442 Q9UKV5 Q8IZ70
Accessions AAA79361 CAH05417 EAW82857 EAW82858 Q9UKV5 AA767223 AF124145 AAD56722 AK023874 AK123962 BC017043 AAH17043 BC051032 BC056869 AAH56869 BC069197 AAH69197 BX345849 BX409690 CA748782 DQ582721 L35233 AAA79362 M63175 AAA36671 W60999 XM_005255889 XP_005255946 XM_005255890 XP_005255947 NM_001144 NP_001135 NM_138958
Function E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97- AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97- AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor. {ECO:0000269|PubMed:10456327, ECO:0000269|PubMed:11724934, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:19103148}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:11724934}; Multi-pass membrane protein {ECO:0000269|PubMed:11724934}.
Top Pathways Protein processing in endoplasmic reticulum

GP78 CRISPR/Cas9 KO Plasmid (h) - sc-402346 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GP78 HDR Plasmid (h) - sc-402346-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GP78 Double Nickase Plasmid (h) - sc-402346-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GP78 Double Nickase Plasmid (h2) - sc-402346-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GP78 CRISPR Activation Plasmid (h) - sc-402346-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GP78 CRISPR Activation Plasmid (h2) - sc-402346-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GP78 Lentiviral Activation Particles (h) - sc-402346-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GP78 Lentiviral Activation Particles (h2) - sc-402346-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GP78 siRNA (h) - sc-43809 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GP78 shRNA Plasmid (h) - sc-43809-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GP78 shRNA (h) Lentiviral Particles - sc-43809-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AMFR/gp78 RNAi - H00000267-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU068841 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3110 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3110 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09227 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09227

AMFR siRNA (Human) - CRH0182 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AMFR/gp78 RNAi - H00000267-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

AMFR - MBS8224941 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human AMFR (NM_001144.5) - SHH235726 from Creative biogene

Category siRNA
Species Reactivities Human

Human AMFR siRNA - orb260684 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AMFR shRNA Plasmid (Human) - CHH0182 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

AMFR miRNA 3'UTR clone - MiUTR3H-05799 from Creative biogene

Species Reactivities Human
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