AMFR

Gene Symbol	AMFR
Entrez Gene	267
Alt Symbol	GP78, RNF45
Species	Human
Gene Type	protein-coding
Description	autocrine motility factor receptor, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase AMFR|RING finger protein 45
Swissprots	P26442 Q9UKV5 Q8IZ70
Accessions	AAA79361 CAH05417 EAW82857 EAW82858 Q9UKV5 AA767223 AF124145 AAD56722 AK023874 AK123962 BC017043 AAH17043 BC051032 BC056869 AAH56869 BC069197 AAH69197 BX345849 BX409690 CA748782 DQ582721 L35233 AAA79362 M63175 AAA36671 W60999 XM_005255889 XP_005255946 XM_005255890 XP_005255947 NM_001144 NP_001135 NM_138958
Function	E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97- AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97- AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor. {ECO:0000269|PubMed:10456327, ECO:0000269|PubMed:11724934, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:19103148}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:11724934}; Multi-pass membrane protein {ECO:0000269|PubMed:11724934}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AMFR protein fragment - ab114887 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

GP78 / AMFR Antibody Blocking Peptide - LS-E3747 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GP78 / AMFR Antibody Blocking Peptide - LS-E6909 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human AMFR/gp78 Protein - H00000267-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

AMFR/gp78 Peptide - P0974 from Novus Biologicals Category Peptide Species Human

AMFR/gp78 Peptide - P0973 from Novus Biologicals Category Peptide Species Human

AMFR-Antibody-C-term-Blocking-Peptide - BP2162b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AMFR-Antibody-Center-Blocking-Peptide - BP14958c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AMFR-Antibody-C-term-Blocking-Peptide - BP2162a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AMFR Blocking Peptide - 33R-2901 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

AMFR / RNF45 (isoform 2) - H00000267-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

AMFR / RNF45 (isoform 2) - H00000267-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

AMFR fusion protein - ag10178 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

AMFR fusion protein - Ag10308 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human AMFR, GST-tagged - AMFR-3783H from Creative Biomart Category Protein Source E. Coli or Yeast Species Human

Recombinant Human Autocrine motility factor receptor, isoform 1(AMFR) - CSB-YP333164HU CSB-EP333164HU CSB-BP333164HU CSB-MP333164HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Autocrine Motility Factor Receptor (AMFR) - RPC294Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Autocrine Motility Factor Receptor (AMFR) - RPC294Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Autocrine Motility Factor Receptor (AMFR) - RPC294Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Autocrine motility factor receptor, isoform 1 (AMFR), Recombinant Protein - MBS1126158 from MyBioSource Category Protein Prices $1,375.00, $1,835.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast Species Human

AMFR/gp78 Recombinant Protein Antigen - NBP2-33917PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

AMFR Peptide, Human - M34GP00552H from Creative Peptides Category Peptide Source Synthetic. Species Human

AMFR Recombinant Protein (OPCD01277) - OPCD01277 from Aviva Systems Biology Category Protein Source E.coli Species Human

E3 ubiquitin-protein ligase AMFR (AMFR), Recombinant Protein - MBS7007743 from MyBioSource Category Protein Prices $1,435.00, $2,420.00, $3,625.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

AMFR/gp78 Recombinant Protein Antigen - NBP2-57987PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Search more