CDKN1B

Gene Symbol CDKN1B
Entrez Gene 1027
Alt Symbol CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Species Human
Gene Type protein-coding
Description cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Other Description cyclin-dependent kinase inhibitor 1B
Swissprots Q9BUS6 Q5U0H2 P46527 Q16307
Accessions AAD14244 AAF21058 AAL78041 ABS17636 BAA76715 BAA88240 CAA59284 CAN37616 CBX53898 EAW96275 P46527 AA833962 AB451291 BAG70105 AB451423 BAG70237 AF247551 AAF69497 AJ616234 CAE82383 AK298335 BAG60584 AK312461 BAG35368 AM392564 CAL37442 AM393540 CAL38417 AM393634 CAL38510 AM393862 CAL38737 AY004255 AAF88142 BC001971 AAH01971 BG701047 BT019553 AAV38360 BT019554 AAV38361 CN311141 CR457399 CAG33680 DA948043 HY097069 HY246392 U10906 AAA20240 NM_004064 NP_004055
Function Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. {ECO:0000269|PubMed:10831586, ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:19075005}.
Subcellular Location Nucleus. Cytoplasm. Endosome {ECO:0000250}. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK- mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen- activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
Top Pathways Viral carcinogenesis, Epstein-Barr virus infection, MicroRNAs in cancer, PI3K-Akt signaling pathway, Cell cycle

Human CDKN1B gene - orb91605 from Biorbyt

Prices $255.00
Sizes 10 μg
Species Human

Human-CDKN1B-cDNA-Clone - DC00893 from Abgent, a WuXi AppTec company

Prices $267.30
Sizes 10 µg
Species Human
Accession BC001971

CDKN1B cDNA (ANA10275) - ANA10275 from Aviva Systems Biology

Prices $189.00
Sizes 1 µg
Accession BC001971

CDKN1B cDNA (ANA10434) - ANA10434 from Aviva Systems Biology

Prices $189.00
Sizes 1 µg
Accession BC001971

CDKN1B - MBS1276820 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC001971

Human CDKN1B ORF Clone (BC001971) - CDCS411590 from Creative biogene

Species Human
Accession P46527
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