CDKN1B

Gene Symbol	CDKN1B
Entrez Gene	1027
Alt Symbol	CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Other Description	cyclin-dependent kinase inhibitor 1B
Swissprots	Q9BUS6 Q5U0H2 P46527 Q16307
Accessions	AAD14244 AAF21058 AAL78041 ABS17636 BAA76715 BAA88240 CAA59284 CAN37616 CBX53898 EAW96275 P46527 AA833962 AB451291 BAG70105 AB451423 BAG70237 AF247551 AAF69497 AJ616234 CAE82383 AK298335 BAG60584 AK312461 BAG35368 AM392564 CAL37442 AM393540 CAL38417 AM393634 CAL38510 AM393862 CAL38737 AY004255 AAF88142 BC001971 AAH01971 BG701047 BT019553 AAV38360 BT019554 AAV38361 CN311141 CR457399 CAG33680 DA948043 HY097069 HY246392 U10906 AAA20240 NM_004064 NP_004055
Function	Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. {ECO:0000269|PubMed:10831586, ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:19075005}.
Subcellular Location	Nucleus. Cytoplasm. Endosome {ECO:0000250}. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK- mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen- activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
Top Pathways	Viral carcinogenesis, Epstein-Barr virus infection, MicroRNAs in cancer, PI3K-Akt signaling pathway, Cell cycle

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® p27 Kip1 siRNA II - 12410 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® p27 Kip1 siRNA I - 12324 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

p27 CRISPR/Cas9 KO Plasmid (h) - sc-400074 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p27 HDR Plasmid (h) - sc-400074-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p27 Double Nickase Plasmid (h) - sc-400074-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p27 Double Nickase Plasmid (h2) - sc-400074-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p27 CRISPR Activation Plasmid (h) - sc-400074-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p27 CRISPR Activation Plasmid (h2) - sc-400074-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p27 Lentiviral Activation Particles (h) - sc-400074-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p27 Lentiviral Activation Particles (h2) - sc-400074-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p27 siRNA (h) - sc-29429 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p27 shRNA Plasmid (h) - sc-29429-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p27 shRNA (h) Lentiviral Particles - sc-29429-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p27 siRNA (h2) - sc-44215 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p27 shRNA Plasmid (h2) - sc-44215-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p27 shRNA (h2) Lentiviral Particles - sc-44215-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU025821 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1010 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1010 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CDKN1B siRNA (Human) - CRH0739 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

p27/Kip1 RNAi - H00001027-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CDKN1B - MBS8212346 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

p27 CRISPR/Cas9 KO Plasmid (h2) - sc-400074-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p27 HDR Plasmid (h2) - sc-400074-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human CDKN1B (NM_004064.3) - SHH260821 from Creative biogene Category siRNA Species Reactivities Human

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