| Gene Symbol |
XPOT
|
| Entrez Gene |
11260
|
| Alt Symbol |
XPO3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
exportin, tRNA
|
| Other Description |
exportin(tRNA)|exportin, tRNA (nuclear export receptor for tRNAs)|exportin-T|tRNA exportin
|
| Swissprots |
O43784 Q9BVS7 Q8WUG2 A6NLH1 O43592
|
| Accessions |
EAW97128 EAW97129 EAW97130 EAW97131 EAW97132 O43592 AF039022 AAC39793 AK098081 AK292884 BAF85573 AK308108 BC000950 AAH00950 BC020569 AAH20569 BQ215290 CR979468 Y16414 CAA76202 XM_011537823 XP_011536125 XR_944484 NM_007235 NP_009166
|
| Function |
Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:12138183, ECO:0000269|PubMed:9512417, ECO:0000269|PubMed:9660920}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm.
|
| Top Pathways |
RNA transport
|