XPOT

Gene Symbol XPOT
Entrez Gene 11260
Alt Symbol XPO3
Species Human
Gene Type protein-coding
Description exportin, tRNA
Other Description exportin(tRNA)|exportin, tRNA (nuclear export receptor for tRNAs)|exportin-T|tRNA exportin
Swissprots O43784 Q9BVS7 Q8WUG2 A6NLH1 O43592
Accessions EAW97128 EAW97129 EAW97130 EAW97131 EAW97132 O43592 AF039022 AAC39793 AK098081 AK292884 BAF85573 AK308108 BC000950 AAH00950 BC020569 AAH20569 BQ215290 CR979468 Y16414 CAA76202 XM_011537823 XP_011536125 XR_944484 NM_007235 NP_009166
Function Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:12138183, ECO:0000269|PubMed:9512417, ECO:0000269|PubMed:9660920}.
Subcellular Location Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm.
Top Pathways RNA transport

Exportin T (17) - sc-136346 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Exportin T (17): sc-136346. Western blot analysis of Exportin T expression in HeLa whole cell lysate.

Exportin T (C-20) - sc-25112 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Exportin T (H-300) - sc-366138 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Exportin T (H-300): sc-366138. Western blot analysis of Exportin T expression in non-transfected 293T: sc-117752 (A), human Exportin T transfected 293T: sc-113431 (B), NCI-H460 (C), Jurkat (D) and ACHN (E) whole cell lysates.

Exportin T (LOS1) - sc-136203 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-Exportin T antibody - ab85365 from Abcam

Prices $369.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Exportin T antibody (ab85365) at 1/100 dilution + Human brain tissue lysate at 50 µgSecondaryHRP-conjugated Goat anti-rabbit IgG at 1/8000 dilutiondeveloped using the ECL techniquePerformed under non-reducing conditions.

Anti-XPOT / Exportin-T Antibody (aa935-962) - LS-C160669 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human brain tissue reacted with XPOT Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-XPOT / Exportin-T Antibody - LS-C65800 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-XPOT / Exportin-T Antibody (clone 3236C1a) - LS-C184429 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3236C1a
Western blot of immunized recombinant protein using XPOT antibody.

Anti-XPOT / Exportin-T Antibody (aa362-411) - LS-C80366 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.

Anti-XPOT / Exportin-T Antibody (aa825-875) - LS-C290615 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse Exportin-T by Western Blot. Samples: Whole cell lysate (50 ug) from 293T, HeLa, Jurkat, and mouse TCMK-1 cells. Antibodies: Affinity purified rabbit anti-Exportin-T antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-XPOT / Exportin-T Antibody (clone 3236C1a) - LS-C342472 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3236C1a
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-XPOT mAb.

Anti-XPOT / Exportin-T Antibody (aa137-166) - LS-C97507 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human lymph with XPOT Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-XPOT / Exportin-T Antibody (aa912-962) - LS-C290618 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Exportin-T by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-Exportin-T antibody used for IP at 6 ug/mg lysate. Exportin-T was inefficiently immunoprecipitated by rabbit anti-Exportin-T antibody A303-972.A. For blotting immunoprecipitated Exportin-T, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Exportin-T Antibody - NBP1-57176 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Exportin-T Antibody [NBP1-57176] - Jurkat cell lysate, concentration 0.2-1 ug/ml.

Exportin-T Antibody - H00011260-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: Exportin-T Antibody [H00011260-B01] - XPOT MaxPab polyclonal antibody. Western Blot analysis of XPOT expression in human kidney.

Exportin-T Antibody - NBP2-13528 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Exportin-T Antibody [NBP2-13528] - Staining of human rectum shows strong cytoplasmic and membranous positivity in glandular cells.

Anti-XPOT antibody produced in rabbit - SAB2102726 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-XPOT: <B>Cat. No.SAB2102726</B>: XPOT in Jurkat cell lysate with XPOT antibody at 1.0 μg/mL.

Monoclonal Anti-Exportin T antibody produced in mouse - E1531 from Sigma-Aldrich

Prices $465.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone Los1
<B>Immunoblotting</B><BR/>Cell extracts from HeLa cells (Human Cervix Epitheloid Carcinoma) were separated by SDS-PAGE, blotted with (Lane 1) or without (Lane 2) Monoclonal Anti-Exportin T, clone Los1 (<B>Cat. No. E1531</B>) and developed using Goat Anti-Mouse IgG-Peroxidase (<B>Cat. No. A2304</B>) and a chemiluminescent substrate.

Anti-XPOT antibody produced in rabbit - HPA038660 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-XPOT:<B>Cat. No. HPA038660</B>: Immunohistochemical staining of human rectum shows strong cytoplasmic and membranous positivity in glandular cells.

Anti-Exportin T antibody produced in chicken - GW21255B from Sigma-Aldrich

Prices $267.50
Sizes 50 µg
Host Chicken
Clonality Polyclonal

XPOT antibody - middle region (ARP40711_P050) - ARP40711_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

XPOT-Antibody-C-term - AP7632b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of XPOT antibody (C-term) (Cat. #AP7632b) in NCI-H460 cell line lysates (35ug/lane). XPOT (arrow) was detected using the purified Pab.

XPOT-Antibody-N-term - AP7632a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of XPOT antibody (N-term) (Cat.#AP7632a) in Ramos cell line lysates (35ug/lane). XPOT (arrow) was detected using the purified Pab.

XPOT Antibody - N-terminal region (OAAB04694) - OAAB04694 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

XPOT Antibody - C-terminal region (OAAB04695) - OAAB04695 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
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