XPOT

Gene Symbol XPOT
Entrez Gene 11260
Alt Symbol XPO3
Species Human
Gene Type protein-coding
Description exportin, tRNA
Other Description exportin(tRNA)|exportin, tRNA (nuclear export receptor for tRNAs)|exportin-T|tRNA exportin
Swissprots O43784 Q9BVS7 Q8WUG2 A6NLH1 O43592
Accessions EAW97128 EAW97129 EAW97130 EAW97131 EAW97132 O43592 AF039022 AAC39793 AK098081 AK292884 BAF85573 AK308108 BC000950 AAH00950 BC020569 AAH20569 BQ215290 CR979468 Y16414 CAA76202 XM_011537823 XP_011536125 XR_944484 NM_007235 NP_009166
Function Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:12138183, ECO:0000269|PubMed:9512417, ECO:0000269|PubMed:9660920}.
Subcellular Location Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm.
Top Pathways RNA transport

Exportin T CRISPR/Cas9 KO Plasmid (h) - sc-407656 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Exportin T HDR Plasmid (h) - sc-407656-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Exportin T Double Nickase Plasmid (h) - sc-407656-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Exportin T Double Nickase Plasmid (h2) - sc-407656-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Exportin T CRISPR Activation Plasmid (h) - sc-407656-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Exportin T CRISPR Activation Plasmid (h2) - sc-407656-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Exportin T Lentiviral Activation Particles (h) - sc-407656-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Exportin T Lentiviral Activation Particles (h2) - sc-407656-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Exportin T siRNA (h) - sc-41275 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Exportin T shRNA Plasmid (h) - sc-41275-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Exportin T shRNA (h) Lentiviral Particles - sc-41275-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU106411 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22982 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22982 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

XPOT siRNA (Human) - CRH7719 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Exportin-T RNAi - H00011260-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

XPOT - MBS8226603 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human XPOT siRNA - orb268221 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

XPOT shRNA Plasmid (Human) - CHH7719 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

XPOT miRNA 3'UTR clone - MiUTR3H-05744 from Creative biogene

Species Reactivities Human
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