CA2

Gene Symbol	CA2
Entrez Gene	760
Alt Symbol	CA-II, CAC, CAII, Car2, HEL-76
Species	Human
Gene Type	protein-coding
Description	carbonic anhydrase II
Other Description	carbonate dehydratase II|carbonic anhydrase 2|carbonic anhydrase B|carbonic anhydrase C|carbonic dehydratase|epididymis luminal protein 76
Swissprots	Q96ET9 P00918 Q6FI12 B2R7G8
Accessions	AAA51909 CAA27012 EAW87136 P00918 AF015039 AK123309 AK312978 BAG35815 BC011949 AAH11949 BC035424 CD013933 CR536526 CAG38763 CR541875 CAG46673 DA431650 DQ891320 ABM82246 DQ894504 ABM85430 FJ224289 ACI45981 J03037 AAA51908 M36532 AAA51911 S69526 AAB30170 Y00339 CAA68426 NM_000067 NP_000058 NM_001293675 NP_001280604
Function	Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. {ECO:0000250, ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:15990874}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15990874}. Cell membrane {ECO:0000269|PubMed:15990874}. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells.
Top Pathways	Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® CA2 siRNA I - 7670 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® CA2 siRNA II - 7589 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

CA II CRISPR/Cas9 KO Plasmid (h) - sc-401059 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CA II HDR Plasmid (h) - sc-401059-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CA II Double Nickase Plasmid (h) - sc-401059-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CA II Double Nickase Plasmid (h2) - sc-401059-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CA II CRISPR Activation Plasmid (h) - sc-401059-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CA II CRISPR Activation Plasmid (h2) - sc-401059-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CA II Lentiviral Activation Particles (h) - sc-401059-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CA II Lentiviral Activation Particles (h2) - sc-401059-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CA II siRNA (h) - sc-29865 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CA II shRNA Plasmid (h) - sc-29865-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CA II shRNA (h) Lentiviral Particles - sc-29865-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Carbonic Anhydrase II/CA2 RNAi - H00000760-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU155141 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5243 from Sigma-Aldrich Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5243 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CA2 siRNA (Human) - CRH0528 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CA2 - MBS8210910 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CA II CRISPR/Cas9 KO Plasmid (h2) - sc-401059-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CA II HDR Plasmid (h2) - sc-401059-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human CA2 (NM_000067.2) - SHH253057 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human CA2(NM_000067.2) - SHG121975 from Creative biogene Category siRNA Species Reactivities Human

CA2 shRNA Plasmid (Human) - CHH0528 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CA2 miRNA 3'UTR clone - MiUTR1H-01561 from Creative biogene Species Reactivities Human

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