HSPA8

Gene Symbol	HSPA8
Entrez Gene	3312
Alt Symbol	HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71
Species	Human
Gene Type	protein-coding
Description	heat shock 70kDa protein 8
Other Description	LPS-associated protein 1|N-myristoyltransferase inhibitor protein 71|constitutive heat shock protein 70|epididymis luminal protein 33|epididymis secretory sperm binding protein Li 72p|heat shock 70kd protein 10|heat shock cognate 71 kDa protein|heat shock cognate protein 54|lipopolysaccharide-associated protein 1
Swissprots	Q9H3R6 P11142
Accessions	CAA68445 EAW67539 EAW67540 EAW67541 EAW67542 P11142 AB034951 BAB18615 AB073886 AF217511 AAF67622 AF352832 AAK17898 AK000571 BAA91262 AK096100 BAG53212 AK129885 AK222628 BAD96348 AK222785 BAD96505 AK292067 BAF84756 AK300404 BAG62134 AK303935 BAG64863 AK310467 BC007276 AAH07276 BC008907 AAH08907 BC015699 AAH15699 BC016179 AAH16179 BC016660 AAH16660 BC019816 AAH19816 BC042163 DC312904 DC395565 DQ891145 ABM82071 DQ894325 ABM85251 EU668349 ACF94502 FJ224294 ACI45986 XM_011542798 XP_011541100 NM_006597 NP_006588 NM_153201 NP_694881
Function	Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP. {ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:23990462}.
Subcellular Location	Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:11276205}.
Top Pathways	Estrogen signaling pathway, Epstein-Barr virus infection, Legionellosis, Influenza A, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HSPA8 / HSC70 ELISA Kit (Sandwich ELISA) - LS-F6167 from LifeSpan Bioscience Category ELISA Kit Prices $580.00 Sizes 1 plate Sensitivity 0.313 ng/ml Range 0.313-20 ng/ml

Rat HSPA8 / HSC70 ELISA Kit (Sandwich ELISA) - LS-F7790 from LifeSpan Bioscience Category ELISA Kit Prices $630.00 Sizes 1 plate Sensitivity 0.103 ng/ml Range 0.313-20 ng/ml

Mouse HSPA8 / HSC70 ELISA Kit (Sandwich ELISA) - LS-F8560 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 0.313-20 ng/ml

Rat HSPA8 / HSC70 ELISA Kit (Sandwich ELISA) - LS-F11671 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.625 Range 0.313-20 ng/ml

Human HSPA8 ELISA Kit - abx151866 from Abbexa Category ELISA Kit Sensitivity 0.134 ng/ml Range 0.313 ng/ml - 20 ng/ml

Heat Shock 70kDa Protein 8 (HSPA8), Human, ELISA Kit - SED063Hu from ARP American Research Products Category ELISA Kit Prices $580.00 Sizes 96 t Sensitivity 0.134ng/mL Range 0.312-20ng/mL

Heat shock cognate 71 kDa protein (HSPA8), Human, ELISA Kit - CSB-EL010829HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

Heat shock cognate 71 kDa protein, HSPA8, Human, ELISA Kit - E1094h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

TNF Receptor Associated Factor 3 (TRAF3), Human, ELISA Kit - SEG753Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 29pg/mL Range 78-5,000pg/mL

heat shock 70kDa protein 8, ELISA Kit - MBS937014 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

Heat Shock 70kDa Protein 8 (HSPA8), ELISA Kit - MBS2023476 from MyBioSource Category ELISA Kit Prices $320.00, $470.00, $630.00, $2,565.00, $4,650.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.128ng/mL. Range 0.313-20ng/mL

Heat Shock 70kDa Protein 8 (HSPA8), ELISA Kit - MBS2019413 from MyBioSource Category ELISA Kit Prices $325.00, $480.00, $645.00, $2,635.00, $4,770.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.116ng/mL. Range 0.313-20ng/mL

Heat Shock 70kDa Protein 8 (HSPA8), ELISA Kit - MBS2024327 from MyBioSource Category ELISA Kit Prices $340.00, $505.00, $675.00, $2,750.00, $5,015.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of rat HSPA8 is typically less than 0.053ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.156-10ng/mL

Heat Shock 70kDa Protein 8 (HSPA8), ELISA Kit - MBS9308577 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Heat shock cognate 71 kDa protein, ELISA Kit - MBS282600 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

HSC70 StressXpress® ELISA Kit - SKT-106-480 from StressMarq Bioscience Category ELISA Kit Prices $2,737.00 Sizes 5 x 96-well Sensitivity 1.54 ng/mL Range 150-2.34ng/mL

HSC70 ELISA kit - SKT-106 from StressMarq Bioscience Category ELISA Kit Prices $644.00 Sizes 96 well Sensitivity 1.54 ng/ml Range 2.34 - 150 ng/mL

HSC70 - MBS806875 from MyBioSource Category ELISA Kit Prices $3,060.00 Sizes 5x96 wells Sensitivity 1.54 ng/mL Range 150-2.34ng/mL

HSC70 - MBS806884 from MyBioSource Category ELISA Kit Prices $820.00 Sizes 1x96 wells Sensitivity 1.54ng/mL Range 150-2.34ng/mL

ELISA Kit for Heat Shock 70kDa Protein 8 (HSPA8) - SED063Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.128ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Heat Shock 70kDa Protein 8 (HSPA8) - SED063Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.116ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Heat Shock 70kDa Protein 8 (HSPA8) - SED063Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.103ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human Heat shock cognate 71 kDa protein(HSPA8) ELISA kit - CSB-EL010829HU from Cusabio Category ELISA Kit Sensitivity 7.8 pg/ml Range 31.25 pg/ml-2000 pg/ml

ELISA Kit for Heat Shock 70kDa Protein 8 (HSPA8) - SED063Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.128ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for TNF Receptor Associated Factor 3 (TRAF3) - SEG753Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 6.3pg/mL. Range 15.625-1000pg/mL The standard curve concentrations used for the ELISA's were 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL, 15.625pg/mL

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