| Gene Symbol |
HSPA8
|
| Entrez Gene |
3312
|
| Alt Symbol |
HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
heat shock 70kDa protein 8
|
| Other Description |
LPS-associated protein 1|N-myristoyltransferase inhibitor protein 71|constitutive heat shock protein 70|epididymis luminal protein 33|epididymis secretory sperm binding protein Li 72p|heat shock 70kd protein 10|heat shock cognate 71 kDa protein|heat shock cognate protein 54|lipopolysaccharide-associated protein 1
|
| Swissprots |
Q9H3R6 P11142
|
| Accessions |
CAA68445 EAW67539 EAW67540 EAW67541 EAW67542 P11142 AB034951 BAB18615 AB073886 AF217511 AAF67622 AF352832 AAK17898 AK000571 BAA91262 AK096100 BAG53212 AK129885 AK222628 BAD96348 AK222785 BAD96505 AK292067 BAF84756 AK300404 BAG62134 AK303935 BAG64863 AK310467 BC007276 AAH07276 BC008907 AAH08907 BC015699 AAH15699 BC016179 AAH16179 BC016660 AAH16660 BC019816 AAH19816 BC042163 DC312904 DC395565 DQ891145 ABM82071 DQ894325 ABM85251 EU668349 ACF94502 FJ224294 ACI45986 XM_011542798 XP_011541100 NM_006597 NP_006588 NM_153201 NP_694881
|
| Function |
Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP. {ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:23990462}.
|
| Subcellular Location |
Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:11276205}.
|
| Top Pathways |
Estrogen signaling pathway, Epstein-Barr virus infection, Legionellosis, Influenza A, Measles
|
![Western Blot: Hsc70 Overexpression Lysate (Adult Normal) [NBL1-11755] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Hsc70.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8129_Hsc70%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11755-img0002.jpg)