HSPA8

Gene Symbol	HSPA8
Entrez Gene	3312
Alt Symbol	HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71
Species	Human
Gene Type	protein-coding
Description	heat shock 70kDa protein 8
Other Description	LPS-associated protein 1|N-myristoyltransferase inhibitor protein 71|constitutive heat shock protein 70|epididymis luminal protein 33|epididymis secretory sperm binding protein Li 72p|heat shock 70kd protein 10|heat shock cognate 71 kDa protein|heat shock cognate protein 54|lipopolysaccharide-associated protein 1
Swissprots	Q9H3R6 P11142
Accessions	CAA68445 EAW67539 EAW67540 EAW67541 EAW67542 P11142 AB034951 BAB18615 AB073886 AF217511 AAF67622 AF352832 AAK17898 AK000571 BAA91262 AK096100 BAG53212 AK129885 AK222628 BAD96348 AK222785 BAD96505 AK292067 BAF84756 AK300404 BAG62134 AK303935 BAG64863 AK310467 BC007276 AAH07276 BC008907 AAH08907 BC015699 AAH15699 BC016179 AAH16179 BC016660 AAH16660 BC019816 AAH19816 BC042163 DC312904 DC395565 DQ891145 ABM82071 DQ894325 ABM85251 EU668349 ACF94502 FJ224294 ACI45986 XM_011542798 XP_011541100 NM_006597 NP_006588 NM_153201 NP_694881
Function	Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP. {ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:23990462}.
Subcellular Location	Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:11276205}.
Top Pathways	Estrogen signaling pathway, Epstein-Barr virus infection, Legionellosis, Influenza A, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active cow Hsc70 full length protein - ab91596 from Abcam Category Protein Prices $345.00 Sizes 50 µg Source E. coli Species Bovine

Active cow Hsc70 protein fragment - ab91597 from Abcam Category Protein Prices $345.00 Sizes 50 µg Source E. coli Species Bovine

Active human Hsc70 full length protein - ab78431 from Abcam Category Protein Prices $239.00 Sizes 50 µg Source E. coli Species Human

Cow Hsc70 full length protein - ab91580 from Abcam Category Protein Prices $339.00 Sizes 50 µg Source E. coli Species Bovine

HSPA8 / HSC70 Antibody Blocking Peptide - LS-E7168 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HSPA8 / HSC70 Antibody Blocking Peptide - LS-E26121 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HSPA8 / HSC70 Antibody Blocking Peptide - LS-E17525 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HSPA8 / HSC70 Antibody Blocking Peptide - LS-E17526 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LAP1 / LRRC7 Antibody Blocking Peptide - LS-E23651 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HSPA8/HSC71/Hsc70 Recombinant Protein - H00003312-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

HSPA8/HSC71/Hsc70 Recombinant Protein - H00003312-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human HSPA8/HSC71/Hsc70 Protein - NBP1-30278 from Novus Biologicals Category Protein Prices $499.00 Sizes 100 µg Source E.coli Species Human

HSPA8-Antibody-C-term-Blocking-Peptide - BP2872b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HSPA8-Antibody-N-term-Blocking-Peptide - BP2872a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HSPA8 Protein (OPPA02182) - OPPA02182 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg

Human Heat Shock 70kDa Protein-8 protein - orb81504 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

Human HSPA8 His tag protein - orb84544 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source E. coli Species Human

HSPA8 peptide - orb217418 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Cat

HSPA8 peptide - orb217417 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey, Cat

Hsc70 Blocking Peptide - 33R-10631 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

HSC70 protein (His tag) - 80R-1214 from Fitzgerald Category Protein Prices $515.00 Sizes 100 µg Source E.coli

HSPA8 Blocking Peptide - 33R-9900 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HSPA8 Blocking Peptide - 33R-6448 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HSC70 Blocking Peptide - abx062748 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Monkey, Pig

HSC70 Blocking Peptide - abx062749 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken

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