Prf1

Gene Symbol Prf1
Entrez Gene 50669
Alt Symbol Cyta, RATCYTA
Species Rat
Gene Type protein-coding
Description perforin 1 (pore forming protein)
Other Description P1|cytolysin|lymphocyte pore-forming protein|perforin-1
Swissprots P35763
Accessions EDL93028 EDL93029 P35763 BC089808 AAH89808 FQ222726 M33605 AAA41071 NM_017330 NP_059026
Function Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. {ECO:0000269|PubMed:2809217}.
Subcellular Location Cytoplasmic granule lumen {ECO:0000269|PubMed:2809217}. Secreted {ECO:0000269|PubMed:2809217}. Cell membrane {ECO:0000269|PubMed:2809217}; Multi-pass membrane protein {ECO:0000269|PubMed:2809217}. Endosome lumen {ECO:0000250}. Note=Stored in cytoplasmic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell. Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change. May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes (By similarity). {ECO:0000250}.
Tissue Specificity Detected in large granular lymphocytes and lymphokine-activated killer cells. {ECO:0000269|PubMed:2809217}.
Top Pathways Natural killer cell mediated cytotoxicity, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Type I diabetes mellitus

Perforin Antibody - NBP1-45775 from Novus Biologicals

Prices $245.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Perforin Antibody [NBP1-45775] - Western blot analysis of Perforin using Jurkat cell lysate (Lane 1 & 2).

Rabbit Anti-Perforin Antibody - 168-10161 from RayBiotech

Host Rabbit

Rabbit Anti-Perforin Antibody - 168-10229 from RayBiotech

Host Rabbit

Monoclonal Antibody to Perforin 1 (PRF1) - MAB317Ra21 from Cloud-clone

Host Mouse
Clonality Monoclonal

Polyclonal Antibody to Perforin 1 (PRF1) - PAB317Ra01 from Cloud-clone

Host Rabbit
Clonality Polyclonal

Perforin Antibody - 3188R-100 from Biovision

Prices $245.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Perforin Antibody - 3287-100 from Biovision

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Perforin, Polyclonal Antibody - MBS840595 from MyBioSource

Prices $150.00, $290.00
Sizes 30 µg, 100 µg
Host Rabbit
Clonality Polyclonal

Perforin - MBS840902 from MyBioSource

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Perforin 1, Polyclonal Antibody - MBS2027439 from MyBioSource

Prices $165.00, $330.00, $510.00
Sizes 20 µg, 100 µg, 200 µg
Host Rabbit
Clonality Polyclonal

Perforin Antibody - AHP2338 from AbD Serotec

Prices $270.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Perforin-Antibody - ABV11512 from Abgent, a WuXi AppTec company

Prices $89.00, $245.00
Sizes 30 µg, 100 µg
Host Rabbit
Clonality Polyclonal

Perforin Antibody - 3188R from Biovision

Prices $89.00, $245.00
Sizes 30 µg, 100 µg
Host Rabbit
Clonality Polyclonal

PERFORIN, Polyclonal Antibody - MBS224844 from MyBioSource

Prices $355.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Perforin-Antibody - ABD13893 from Abgent, a WuXi AppTec company

Clonality Polyclonal
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