Prf1

Gene Symbol	Prf1
Entrez Gene	50669
Alt Symbol	Cyta, RATCYTA
Species	Rat
Gene Type	protein-coding
Description	perforin 1 (pore forming protein)
Other Description	P1|cytolysin|lymphocyte pore-forming protein|perforin-1
Swissprots	P35763
Accessions	EDL93028 EDL93029 P35763 BC089808 AAH89808 FQ222726 M33605 AAA41071 NM_017330 NP_059026
Function	Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. {ECO:0000269|PubMed:2809217}.
Subcellular Location	Cytoplasmic granule lumen {ECO:0000269|PubMed:2809217}. Secreted {ECO:0000269|PubMed:2809217}. Cell membrane {ECO:0000269|PubMed:2809217}; Multi-pass membrane protein {ECO:0000269|PubMed:2809217}. Endosome lumen {ECO:0000250}. Note=Stored in cytoplasmic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell. Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change. May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes (By similarity). {ECO:0000250}.
Tissue Specificity	Detected in large granular lymphocytes and lymphokine-activated killer cells. {ECO:0000269|PubMed:2809217}.
Top Pathways	Natural killer cell mediated cytotoxicity, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Type I diabetes mellitus

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Perforin-1, Prf1, Rat, ELISA Kit - E1317r from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Rat PRF1 ELISA Kit - RP0146 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Rat PRF1(Perforin 1) ELISA Kit - E-EL-R0721 from Elabscience Category ELISA Kit Sensitivity 0.19 ng/mL Range 0.31—20 ng/mL

Rat PRF1 (Perforin 1) CLIA Kit - E-CL-R0510 from Elabscience Category CLIA Kit Sensitivity 37.50 pg/mL Range Average Recovery (%)

Rat Perforin 1 ELISA - E02P0139 from BlueGene Biotech Category ELISA Kit Sensitivity 0.1 ng/mL

ELISA Kit for Perforin 1 (PRF1) - SEB317Ra from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Rat PRF1(Perforin 1) ELISA Kit - E-EL-R0721 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.19 ng/mL Range 0.31~20 ng/mL

Rat PRF1 (Perforin 1) CLIA Kit - E-CL-R0510 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 0.188ng/mL Range 0.313-20ng/mL

Rat Perforin-1 ELISA Kit - abx256479 from Abbexa Category ELISA Kit Range 0.313 ng/ml - 20 ng/ml

Perforin 1 (PRF1), Rat, ELISA Kit - DL-PRF1-Ra from ARP American Research Products Category ELISA Kit Prices $715.00 Sizes 96 t Range 0.312-20 ng/mL

Rat PRF1 ELISA Kit - abx572378 from Abbexa Category ELISA Kit Sensitivity 0.18 ng/ml Range 0.313 ng/ml - 20 ng/ml

Rat Perforin-1 ELISA Kit - EKE53866 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Range 0.156-10 ng/mL

Prf1 - EKR1004 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.313-20ng/ml

Rat Prf1 ELISA Kit - E093264 from Biobool Category ELISA Kit

Prf1 ELISA Kit (Rat) (OKEH04822) - OKEH04822 from Aviva Systems Biology Category ELISA Kit Prices $425.00 Sizes 96 wells Sensitivity < 0.07 ng/mL Range 0.156 - 10 ng/mL

Rat PRF1 ELISA Kit - ERP0146 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

Rat Perforin-1 (PRF1) ELISA Kit - AE26041RA from ARP American Research Products Category ELISA Kit Prices $610.00 Sizes 96 t Sensitivity 0.059 ng/mL Range 0.156-10 ng/mL

Rat Sperm protamine P1 (PRM1) ELISA Kit - AE25875RA from ARP American Research Products Category ELISA Kit Prices $610.00 Sizes 96 t

Perforin 1 (PRF1), ELISA Kit - MBS453216 from MyBioSource Category ELISA Kit Prices $425.00, $565.00, $2,485.00, $4,830.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.18ng/mL Range 0.312-20ng/mL

Perforin-1, ELISA Kit - MBS2883872 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.15 ng/mL -10.0 ng/mL.

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