| Gene Symbol |
Prf1
|
| Entrez Gene |
50669
|
| Alt Symbol |
Cyta, RATCYTA
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
perforin 1 (pore forming protein)
|
| Other Description |
P1|cytolysin|lymphocyte pore-forming protein|perforin-1
|
| Swissprots |
P35763
|
| Accessions |
EDL93028 EDL93029 P35763 BC089808 AAH89808 FQ222726 M33605 AAA41071 NM_017330 NP_059026
|
| Function |
Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. {ECO:0000269|PubMed:2809217}.
|
| Subcellular Location |
Cytoplasmic granule lumen {ECO:0000269|PubMed:2809217}. Secreted {ECO:0000269|PubMed:2809217}. Cell membrane {ECO:0000269|PubMed:2809217}; Multi-pass membrane protein {ECO:0000269|PubMed:2809217}. Endosome lumen {ECO:0000250}. Note=Stored in cytoplasmic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell. Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change. May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Detected in large granular lymphocytes and lymphokine-activated killer cells. {ECO:0000269|PubMed:2809217}.
|
| Top Pathways |
Natural killer cell mediated cytotoxicity, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Type I diabetes mellitus
|