| Gene Symbol |
NOS3
|
| Entrez Gene |
287024
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
nitric oxide synthase 3 (endothelial cell)
|
| Other Description |
EC-NOS|NOS type III|NOSIII|cNOS|constitutive NOS|eNOS|endothelial NOS|endothelial nitric oxide synthase|nitric oxide synthase, endothelial
|
| Swissprots |
P29473
|
| Accessions |
CAA02941 DAA30266 P29473 M89952 AAA30494 M95674 AAA30669 M99057 AAA30667 NM_181037 NP_851380
|
| Function |
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:17071725}. Membrane, caveola {ECO:0000269|PubMed:17071725}. Cytoplasm, cytoskeleton {ECO:0000250}. Golgi apparatus {ECO:0000269|PubMed:17071725}. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity. {ECO:0000250}.
|
| Top Pathways |
Sphingolipid signaling pathway, cGMP-PKG signaling pathway, Oxytocin signaling pathway, Estrogen signaling pathway, PI3K-Akt signaling pathway
|