KLRK1

Gene Symbol	KLRK1
Entrez Gene	22914
Alt Symbol	CD314, D12S2489E, KLR, NKG2-D, NKG2D
Species	Human
Gene Type	protein-coding
Description	killer cell lectin-like receptor subfamily K, member 1
Other Description	NK cell receptor D|NKG2-D type II integral membrane protein|NKG2-D-activating NK receptor
Swissprots	A8K7P4 A8K7K5 Q9NR41 P26718
Accessions	ABF50044 CAA04925 EAW96178 EAW96180 EAW96182 P26718 AF260135 AAF86973 AF260136 AAF86974 AK226161 AK292059 BAF84748 BC039836 AAH39836 CB241686 DA933271 DA960048 NM_007360 NP_031386
Function	Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. {ECO:0000269|PubMed:10426994, ECO:0000269|
Subcellular Location	Cell membrane {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}; Single- pass type II membrane protein {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}. Note=Colocalized with HCST on the cell surface.
Tissue Specificity	Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs). {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:15294961, ECO:0000269|PubMed:16444266}.
Top Pathways	Natural killer cell mediated cytotoxicity, Malaria

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NKG2-D (5C6) - sc-53501 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

NKG2-D (1D11) - sc-23869 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

NKG2-D (C-14) - sc-5455 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

NKG2-D (H-65) - sc-292424 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

NKG2-D (N-20) - sc-9621 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-KLRK1 / CD314 / NKG2D Antibody (Low Endotoxin) - LS-C44804 from LifeSpan Bioscience Prices $445.00 Sizes 500 µg Host Mouse Clonality Monoclonal

Anti-KLRK1 / CD314 / NKG2D Antibody - LS-C44803 from LifeSpan Bioscience Prices $370.00 Sizes 200 µg Host Mouse Clonality Monoclonal

Anti-KLRK1 / CD314 / NKG2D Antibody (FITC) - LS-C44805 from LifeSpan Bioscience Prices $330.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-KLRK1 / CD314 / NKG2D Antibody - LS-C44801 from LifeSpan Bioscience Prices $375.00 Sizes 200 µg Host Mouse Clonality Monoclonal

Anti-KLRK1 / CD314 / NKG2D Antibody (RPE) - LS-C44806 from LifeSpan Bioscience Prices $350.00 Sizes 100 tst Host Mouse Clonality Monoclonal

Anti-KLRK1 / CD314 / NKG2D Antibody - LS-C130372 from LifeSpan Bioscience Host Hamster Clonality Monoclonal

Anti-KLRK1 / CD314 / NKG2D Antibody (PE) - LS-C130370 from LifeSpan Bioscience Prices $455.00 Sizes 100 tst Host Mouse Clonality Monoclonal

Anti-KLRK1 / CD314 / NKG2D Antibody - LS-C123954 from LifeSpan Bioscience Prices $575.00 Sizes 500 µg Host Mouse Clonality Monoclonal

Anti-KLRK1 / CD314 / NKG2D Antibody (clone 1D11) - LS-C123953 from LifeSpan Bioscience Prices $485.00 Sizes 200 µg Host Mouse Clonality Monoclonal Clone 1D11

Anti-KLRK1 / CD314 / NKG2D Antibody (aa136-147) - LS-C20184 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-KLRK1 / CD314 / NKG2D Antibody (clone 1D11, Azide-free) - LS-C204360 from LifeSpan Bioscience Prices $255.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1D11

Anti-KLRK1 / CD314 / NKG2D Antibody (clone 1D11, APC) - LS-C204393 from LifeSpan Bioscience Prices $315.00 Sizes 100 tst Host Mouse Clonality Monoclonal Clone 1D11

Anti-KLRK1 / CD314 / NKG2D Antibody (clone 1D11, PE) - LS-C204454 from LifeSpan Bioscience Prices $315.00 Sizes 100 tst Host Mouse Clonality Monoclonal Clone 1D11

Anti-KLRK1 / CD314 / NKG2D Antibody (clone 1D11, FITC) - LS-C204417 from LifeSpan Bioscience Prices $290.00 Sizes 100 tst Host Mouse Clonality Monoclonal Clone 1D11

Anti-KLRK1 / CD314 / NKG2D Antibody (aa111-160) - LS-C291454 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KLRK1 / CD314 / NKG2D Antibody - LS-C341928 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KLRK1 / CD314 / NKG2D Antibody (C-Terminus) - LS-C146470 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-KLRK1 / CD314 / NKG2D Antibody (aa121-170) - LS-C146469 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-KLRK1 / CD314 / NKG2D Antibody (clone CX5) - LS-C106909 from LifeSpan Bioscience Prices $235.00, $295.00, $375.00 Sizes 50 µg, 100 µg, 500 µg Host Rat Clonality Monoclonal Clone CX5

Anti-KLRK1 / CD314 / NKG2D Antibody - LS-C335641 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Search more