Gene Symbol | KLRK1 |
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Entrez Gene | 22914 |
Alt Symbol | CD314, D12S2489E, KLR, NKG2-D, NKG2D |
Species | Human |
Gene Type | protein-coding |
Description | killer cell lectin-like receptor subfamily K, member 1 |
Other Description | NK cell receptor D|NKG2-D type II integral membrane protein|NKG2-D-activating NK receptor |
Swissprots | A8K7P4 A8K7K5 Q9NR41 P26718 |
Accessions | ABF50044 CAA04925 EAW96178 EAW96180 EAW96182 P26718 AF260135 AAF86973 AF260136 AAF86974 AK226161 AK292059 BAF84748 BC039836 AAH39836 CB241686 DA933271 DA960048 NM_007360 NP_031386 |
Function | Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. {ECO:0000269|PubMed:10426994, ECO:0000269| |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}; Single- pass type II membrane protein {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}. Note=Colocalized with HCST on the cell surface. |
Tissue Specificity | Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs). {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:15294961, ECO:0000269|PubMed:16444266}. |
Top Pathways | Natural killer cell mediated cytotoxicity, Malaria |
Human KLR ELISA Kit - abx054216 from Abbexa
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NKG2-D type II integral membrane protein (KLRK1), Human, ELISA Kit - CSB-EL012474HU from ARP American Research Products
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NKG2-D type II integral membrane protein (KLRK1), Human, ELISA Kit - E01N0528 from ARP American Research Products
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NKG2 D type II integral membrane protein (KLRK1), ELISA Kit - MBS7247261 from MyBioSource
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NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7201304 from MyBioSource
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NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7224099 from MyBioSource
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NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7242024 from MyBioSource
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NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7214171 from MyBioSource
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NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7207013 from MyBioSource
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NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7221141 from MyBioSource
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NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7212975 from MyBioSource
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NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7224282 from MyBioSource
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Human NKG2-D type II integral membrane protein(KLRK1) ELISA kit - CSB-EL012474HU from Cusabio
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Custom Human CD314 ELISA Kit - orb384502 from Biorbyt
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Human KLRK1 ELISA Kit - E021788 from Biobool
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Human KLR ELISA Kit - E021790 from Biobool
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anti-CD314 antibody [1D11] (azide free) - ARG65377 from Arigo Biolaboratories
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anti-CD314 antibody [1D11] - ARG65378 from Arigo Biolaboratories
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anti-NKG2D / KLRK1 antibody - ARG63802 from Arigo Biolaboratories
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anti-CD314 antibody [1D11] (APC) - ARG54193 from Arigo Biolaboratories
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anti-CD314 antibody [1D11] (PE) - ARG54194 from Arigo Biolaboratories
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anti-CD314 antibody [1D11] (FITC) - ARG65379 from Arigo Biolaboratories
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KLRK1 ELISA Kit (Human) (OKCA01392) - OKCA01392 from Aviva Systems Biology
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NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7240270 from MyBioSource
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