KLRK1

Gene Symbol KLRK1
Entrez Gene 22914
Alt Symbol CD314, D12S2489E, KLR, NKG2-D, NKG2D
Species Human
Gene Type protein-coding
Description killer cell lectin-like receptor subfamily K, member 1
Other Description NK cell receptor D|NKG2-D type II integral membrane protein|NKG2-D-activating NK receptor
Swissprots A8K7P4 A8K7K5 Q9NR41 P26718
Accessions ABF50044 CAA04925 EAW96178 EAW96180 EAW96182 P26718 AF260135 AAF86973 AF260136 AAF86974 AK226161 AK292059 BAF84748 BC039836 AAH39836 CB241686 DA933271 DA960048 NM_007360 NP_031386
Function Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. {ECO:0000269|PubMed:10426994, ECO:0000269|
Subcellular Location Cell membrane {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}; Single- pass type II membrane protein {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}. Note=Colocalized with HCST on the cell surface.
Tissue Specificity Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs). {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:15294961, ECO:0000269|PubMed:16444266}.
Top Pathways Natural killer cell mediated cytotoxicity, Malaria

Human KLR ELISA Kit - abx054216 from Abbexa

Category ELISA Kit

NKG2-D type II integral membrane protein (KLRK1), Human, ELISA Kit - CSB-EL012474HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

NKG2-D type II integral membrane protein (KLRK1), Human, ELISA Kit - E01N0528 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

NKG2 D type II integral membrane protein (KLRK1), ELISA Kit - MBS7247261 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7201304 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7224099 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7242024 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7214171 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7207013 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7221141 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7212975 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7224282 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human NKG2-D type II integral membrane protein(KLRK1) ELISA kit - CSB-EL012474HU from Cusabio

Category ELISA Kit
Sensitivity 0.078 ng/ml
Range 0.312 ng/ml-20 ng/ml

Custom Human CD314 ELISA Kit - orb384502 from Biorbyt

Category ELISA Kit
Prices $1,411.00, $2,448.00, $5,321.00
Sizes 96 assays, 192 assays, 480 assays

Human KLRK1 ELISA Kit - E021788 from Biobool

Category ELISA Kit
Sensitivity The minimum detectable dose of human KLRK1 is typically less than 5.86 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the me

Human KLR ELISA Kit - E021790 from Biobool

Category ELISA Kit

anti-CD314 antibody [1D11] (azide free) - ARG65377 from Arigo Biolaboratories

Category ELISA Kit

anti-CD314 antibody [1D11] - ARG65378 from Arigo Biolaboratories

Category ELISA Kit

anti-NKG2D / KLRK1 antibody - ARG63802 from Arigo Biolaboratories

Category ELISA Kit

anti-CD314 antibody [1D11] (APC) - ARG54193 from Arigo Biolaboratories

Category ELISA Kit

anti-CD314 antibody [1D11] (PE) - ARG54194 from Arigo Biolaboratories

Category ELISA Kit

anti-CD314 antibody [1D11] (FITC) - ARG65379 from Arigo Biolaboratories

Category ELISA Kit

KLRK1 ELISA Kit (Human) (OKCA01392) - OKCA01392 from Aviva Systems Biology

Category ELISA Kit
Prices $600.00
Sizes 96 wells
Sensitivity 0.078 ng/mL
Range 0.312 - 20 ng/mL

NKG2-D type II integral membrane protein (KLRK1), ELISA Kit - MBS7240270 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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