| Gene Symbol | KLRK1 |
|---|---|
| Entrez Gene | 22914 |
| Alt Symbol | CD314, D12S2489E, KLR, NKG2-D, NKG2D |
| Species | Human |
| Gene Type | protein-coding |
| Description | killer cell lectin-like receptor subfamily K, member 1 |
| Other Description | NK cell receptor D|NKG2-D type II integral membrane protein|NKG2-D-activating NK receptor |
| Swissprots | A8K7P4 A8K7K5 Q9NR41 P26718 |
| Accessions | ABF50044 CAA04925 EAW96178 EAW96180 EAW96182 P26718 AF260135 AAF86973 AF260136 AAF86974 AK226161 AK292059 BAF84748 BC039836 AAH39836 CB241686 DA933271 DA960048 NM_007360 NP_031386 |
| Function | Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. {ECO:0000269|PubMed:10426994, ECO:0000269| |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}; Single- pass type II membrane protein {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}. Note=Colocalized with HCST on the cell surface. |
| Tissue Specificity | Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs). {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:15294961, ECO:0000269|PubMed:16444266}. |
| Top Pathways | Natural killer cell mediated cytotoxicity, Malaria |
NKG2-D CRISPR/Cas9 KO Plasmid (h) - sc-416848 from Santa Cruz Biotechnology
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NKG2-D HDR Plasmid (h) - sc-416848-HDR from Santa Cruz Biotechnology
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NKG2-D Double Nickase Plasmid (h) - sc-416848-NIC from Santa Cruz Biotechnology
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NKG2-D Double Nickase Plasmid (h2) - sc-416848-NIC-2 from Santa Cruz Biotechnology
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NKG2-D CRISPR Activation Plasmid (h) - sc-416848-ACT from Santa Cruz Biotechnology
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NKG2-D CRISPR Activation Plasmid (h2) - sc-416848-ACT-2 from Santa Cruz Biotechnology
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NKG2-D Lentiviral Activation Particles (h) - sc-416848-LAC from Santa Cruz Biotechnology
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NKG2-D Lentiviral Activation Particles (h2) - sc-416848-LAC-2 from Santa Cruz Biotechnology
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NKG2-D siRNA (h) - sc-42948 from Santa Cruz Biotechnology
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NKG2-D shRNA Plasmid (h) - sc-42948-SH from Santa Cruz Biotechnology
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NKG2-D shRNA (h) Lentiviral Particles - sc-42948-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU128171 from Sigma-Aldrich
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MISSION® esiRNA - EHU225531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11331 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11331 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12327 from Sigma-Aldrich
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KLRK1 siRNA (Human) - CRH7867 from Cohesion Biosciences
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shRNA set against Human KLRK1 (NM_007360.3) - SHH326911 from Creative biogene
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Human KLRK1 siRNA - orb268369 from Biorbyt
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KLRK1 shRNA Plasmid (Human) - CHH7867 from Cohesion Biosciences
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KLRK1 miRNA 3'UTR clone - MiUTR3H-12119 from Creative biogene
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