ALOX15

Gene Symbol ALOX15
Entrez Gene 246
Alt Symbol 12-LOX, 15-LOX-1, 15LOX-1
Species Human
Gene Type protein-coding
Description arachidonate 15-lipoxygenase
Other Description 12/15-lipoxygenase|15-LOX|15-lipooxygenase-1|arachidonate 12-lipoxygenase, leukocyte-type|arachidonate omega-6 lipoxygenase
Swissprots P16050 Q99657 B7ZA11 A8K2P4 Q8N6R7
Accessions AAB49305 AAC52118 AAR84235 EAW90427 EAW90428 P16050 AK290309 BAF82998 AK296792 BAH12431 AK296821 BAH12437 AK296904 BAH12452 AK312557 BAG35454 AK316126 BAH14497 BC029032 AAH29032 M23892 AAA36182 M95923 AAA35482 NM_001140 NP_001131
Function Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12- hydroperoxyeicosatetraenoic acid/12-HPETE and 15- hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function throug
Subcellular Location Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Lipid droplet. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding. Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells.
Tissue Specificity Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells. {ECO:0000269|PubMed:21831839, ECO:0000269|PubMed:9414270}.
Top Pathways Arachidonic acid metabolism, Linoleic acid metabolism

15-LO (B-7) - sc-133085 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
15-LO (B-7): sc-133085. Western blot analysis of 15-LO expression in HEK293 cells transfected with human 15-LO expression vector (A) and HEK923 cells (B).

15-LO (H-235) - sc-32940 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
15-LO (H-235): sc-32940. Western blot analysis of 15-LO expression in non-transfected 293T: sc-117752 (A), human 15-LO transfected 293T: sc-114262 (B) and human PBL (C) whole cell lysates.

15-LO (V-17) - sc-27354 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
15-LO (V-17): sc-27354. Western blot analysis of 15-LO expression in non-transfected: sc-117752 (A) and human 15-LO transfected: sc-114262 (B) 293T whole cell lysates.

Anti-15 Lipoxygenase 1 antibody - ab131116 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skeletal muscle tissue labelling 15 Lipoxygenase 1 with ab131116 at 2 µg/ml.

Anti-15 Lipoxygenase 1 antibody - ab80495 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-15 Lipoxygenase 1 antibody (ab80495) at 0.2 µg/ml + nuclear HeLa cell lysate (in RIPA buffer) at 35 µg

Anti-15 Lipoxygenase 1 antibody - ab195432 from Abcam

Prices $359.00
Sizes 50 µl
Host Sheep
Clonality Polyclonal

Anti-15 Lipoxygenase 1 antibody - ab54772 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-15 Lipoxygenase 1 antibody [3D8] - ab110100 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3D8
Anti-15 Lipoxygenase 1 antibody [3D8] (ab110100) + HeLa nuclear extracts at 50 µg

Anti-15 Lipoxygenase 1 antibody [3G8] - ab119774 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G8
All lanes : Anti-15 Lipoxygenase 1 antibody [3G8] (ab119774) at 1/500 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control Lane 2 : HEK293T cells transfected with pCMV6-ENTRY 15 Lipoxygenase 1 cDNALysates/proteins at 5 µg per lane.

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa539-588) - LS-C111783 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ALOX15 / 15 Lipoxygenase 1 antibody LS-C111783 Western blot of Fetal Heart lysate.

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa170-312, Biotin) - LS-C299109 from LifeSpan Bioscience

Prices $405.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa170-312, Biotin) - LS-C300672 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa170-312, FITC) - LS-C304281 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa170-312, FITC) - LS-C304832 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa170-312) - LS-C292377 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Western blot of recombinant 15-LOX / ALOX15.

Anti-ALOX15 / 15-Lipoxygenase Antibody (clone 8C5) - LS-C173721 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8C5
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ALOX15 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ALOX15.

Anti-ALOX15 / 15-Lipoxygenase Antibody - LS-C309426 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa170-312) - LS-C292930 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant 15-LOX / ALOX15.

Anti-ALOX15 / 15-Lipoxygenase Antibody IHC-plus™ - LS-B7902 from LifeSpan Bioscience

Prices $395.00
Sizes 1 ea
Host Sheep
Clonality Polyclonal
Anti-15-LOX / ALOX15 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7902 dilution 5 ug/ml.

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa610-643) - LS-C99452 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human lymph tissue reacted with ALOX15 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-ALOX15 / 15-Lipoxygenase Antibody (clone 3D8) IHC-plus™ - LS-B4278 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3D8
Anti-ALOX15 / 15 Lipoxygenase 1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4278 concentration 5 ug/ml.

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa2-337) - LS-C343940 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ALOX15 antibody IHC-paraffin: Human Intestine Cancer Tissue.

Anti-ALOX15 / 15-Lipoxygenase Antibody (clone 2G3) - LS-C173699 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2G3
IHC of paraffin-embedded Human lymphoma tissue using anti-ALOX15 mouse monoclonal antibody.

Anti-ALOX15 / 15-Lipoxygenase Antibody (clone 7H6) IHC-plus™ - LS-B12236 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 7H6
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa482-494) IHC-plus™ - LS-B6689 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-ALOX15 / 15 Lipoxygenase 1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6689 concentration 2 ug/ml.
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