ALOX15

Gene Symbol	ALOX15
Entrez Gene	246
Alt Symbol	12-LOX, 15-LOX-1, 15LOX-1
Species	Human
Gene Type	protein-coding
Description	arachidonate 15-lipoxygenase
Other Description	12/15-lipoxygenase|15-LOX|15-lipooxygenase-1|arachidonate 12-lipoxygenase, leukocyte-type|arachidonate omega-6 lipoxygenase
Swissprots	P16050 Q99657 B7ZA11 A8K2P4 Q8N6R7
Accessions	AAB49305 AAC52118 AAR84235 EAW90427 EAW90428 P16050 AK290309 BAF82998 AK296792 BAH12431 AK296821 BAH12437 AK296904 BAH12452 AK312557 BAG35454 AK316126 BAH14497 BC029032 AAH29032 M23892 AAA36182 M95923 AAA35482 NM_001140 NP_001131
Function	Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12- hydroperoxyeicosatetraenoic acid/12-HPETE and 15- hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function throug
Subcellular Location	Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Lipid droplet. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding. Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells.
Tissue Specificity	Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells. {ECO:0000269|PubMed:21831839, ECO:0000269|PubMed:9414270}.
Top Pathways	Arachidonic acid metabolism, Linoleic acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ALOX15 / 15-Lipoxygenase ELISA Kit (Sandwich ELISA) - LS-F9552 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.55 ng/ml Range 1.56-100 ng/ml

Human ALOX15 ELISA Kit - abx150618 from Abbexa Category ELISA Kit Sensitivity 0.57 ng/ml Range 1.563 ng/ml - 100 ng/ml

Arachidonate 15-Lipoxygenase, 15-LO, Human, ELISA Kit - E-EL-H0209 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 37.5 Range 62.5-4000pg/mL

Arachidonate 15-lipoxygenase (ALOX15/LOG15), Human, ELISA Kit - E01A1400 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Arachidonate 15-lipoxygenase, ALOX15, Human, ELISA Kit - E0891h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Arachidonate-15-Lipoxygenase (ALOX15), Human, ELISA Kit - SEA891Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.57ng/mL Range 1.56-100ng/mL

Arachidonate 15-Lipoxygenase, 15-LO, Mouse, ELISA Kit - E-EL-M1280 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Arachidonate 15-Lipoxygenase, 15-LO, Rat, ELISA Kit - E-EL-R1001 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 18.75 Range 31.25-2000pg/mL

Arachidonate 15-Lipoxygenase, 15-LO, Rabbit, ELISA Kit - E-EL-RB1148 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Arachidonate 15-Lipoxygenase, 15-LO, Porcine, ELISA Kit - E-EL-P0119 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Arachidonate 15-Lipoxygenase, 15-LO, Guinea Pig, ELISA Kit - E-EL-GP0830 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Arachidonate 15-Lipoxygenase, 15-LO, Monkey, ELISA Kit - E-EL-MK2025 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

ALOX15 (Human) Matched Antibody Pair - H00000246-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Arachidonate 15 lipoxygenase (ALOX15/LOG15), ELISA Kit - MBS7250533 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 15-lipoxygenase (ALOX15/LOG15), ELISA Kit - MBS7246406 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Arachidonate 15-lipoxygenase (ALOX15/LOG15), ELISA Kit - MBS7203785 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

12 Lipoxygenase, ELISA Kit - MBS730723 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,850.00, $5,340.00 Sizes 48 -strip-wells- (Competitive), 96 -strip-wells- (Competitive), 5x96-strip-wells- (Competitive), 10x96-strip-wells- (Competitive) Sensitivity 0.1 ng/mL.

12-Lipoxygenase, ELISA Kit - MBS029712 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

12-Lipoxygenase, ELISA Kit - MBS042770 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

12-Lipoxygenase, ELISA Kit - MBS029217 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

12-Lipoxygenase, ELISA Kit - MBS723492 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

12-Lipoxygenase, ELISA Kit - MBS045605 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

12-Lipoxygenase, ELISA Kit - MBS009257 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.25ng/ml-8ng/ml.

12-Lipoxygenase, ELISA Kit - MBS013108 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

12-Lipoxygenase, ELISA Kit - MBS733497 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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