ALOX15

Gene Symbol	ALOX15
Entrez Gene	246
Alt Symbol	12-LOX, 15-LOX-1, 15LOX-1
Species	Human
Gene Type	protein-coding
Description	arachidonate 15-lipoxygenase
Other Description	12/15-lipoxygenase|15-LOX|15-lipooxygenase-1|arachidonate 12-lipoxygenase, leukocyte-type|arachidonate omega-6 lipoxygenase
Swissprots	P16050 Q99657 B7ZA11 A8K2P4 Q8N6R7
Accessions	AAB49305 AAC52118 AAR84235 EAW90427 EAW90428 P16050 AK290309 BAF82998 AK296792 BAH12431 AK296821 BAH12437 AK296904 BAH12452 AK312557 BAG35454 AK316126 BAH14497 BC029032 AAH29032 M23892 AAA36182 M95923 AAA35482 NM_001140 NP_001131
Function	Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12- hydroperoxyeicosatetraenoic acid/12-HPETE and 15- hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function throug
Subcellular Location	Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Lipid droplet. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding. Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells.
Tissue Specificity	Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells. {ECO:0000269|PubMed:21831839, ECO:0000269|PubMed:9414270}.
Top Pathways	Arachidonic acid metabolism, Linoleic acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human 15 Lipoxygenase 1 full length protein - ab114421 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

ALOX15 / 15-Lipoxygenase Antibody Blocking Peptide - LS-E20295 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ALOX15 / 15-Lipoxygenase Antibody Blocking Peptide - LS-E9355 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ALOX15 / 15-Lipoxygenase Antibody Blocking Peptide - LS-E26930 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human 15-Lipoxygenase 1 Protein - H00000246-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ALOX15-Antibody-C-term-Blocking-Peptide - BP7896b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ALOX15 blocking peptide - GTX88501-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

ALOX15 Blocking Peptide - 33R-7578 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human ALOX15 Protein - abx065449 from Abbexa Category Protein Source E.coli Species Human

15 Lipoxygenase 1 Peptide - AC21-1759-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ALOX15 / LOG15 - H00000246-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ALOX15 / LOG15 - H00000246-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Arachidonate-15-Lipoxygenase (ALOX15), Human - 20-7297 from ARP American Research Products Category Protein Prices $549.00 Sizes 50 µg Source E.coli Species Human

ALOX15 Peptide - 46-769P from ProSci Category Peptide Species Human

ALOX15 fusion protein - ag4040 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

ALOX15 Active Human Recombinant Protein - GWB-6672E3 from Genway Biotech Category Protein Prices $566.00 Sizes 20 µg Species Human

Recombinant Arachidonate-15-Lipoxygenase (ALOX15) - RPA891Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Arachidonate-15-Lipoxygenase (ALOX15) - RPA891Hu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Arachidonate-15-Lipoxygenase (ALOX15) - RPA891Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Arachidonate-15-Lipoxygenase (ALOX15) - RPA891Hu02 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Arachidonate 15-lipoxygenase(ALOX15) - CSB-YP001621HU CSB-EP001621HU CSB-BP001621HU CSB-MP001621HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ALOX15 Protein - abx164242 from Abbexa Category Protein Species Human, Mouse, Rat

ALOX15 / LOG15 - TP306621 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Arachidonate 15-lipoxygenase (ALOX15) , Recombinant Protein - MBS949600 from MyBioSource Category Protein Prices $2,485.00, $2,485.00, $2,905.00, $2,905.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Arachidonate-15-Lipoxygenase, Recombinant Protein - MBS2031429 from MyBioSource Category Protein Prices $240.00, $430.00, $620.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

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