Neu1

Gene Symbol Neu1
Entrez Gene 18010
Alt Symbol AA407268, AA407316, Aglp, Apl, Bat-7, Bat7, G9, Map-2, Neu, Neu-1
Species Mouse
Gene Type protein-coding
Description neuraminidase 1
Other Description G9 sialidase|HLA-B-associated transcript 7|N-acetyl-alpha-neuraminidase 1|lysosomal sialidase|sialidase 1|sialidase-1
Swissprots O55220 Q99KG9 O35657
Accessions AAC84167 CAD91185 EDL26719 EDL26720 EDL26721 O35657 AK077444 AK138332 AK145680 BAE26586 AK148229 AK182863 AK186151 AK186636 AK187229 AK187684 AK189610 AK190751 AK193377 AK200662 AK200961 AK210577 AK212019 BC004666 AAH04666 BY281600 U93702 AAC53536 Y11412 CAA72215 NM_010893 NP_035023
Function Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. {ECO:0000269|PubMed:9363440, ECO:0000269|PubMed:9384611}.
Subcellular Location Lysosome membrane {ECO:0000269|PubMed:9384611}; Peripheral membrane protein {ECO:0000269|PubMed:9384611}; Lumenal side {ECO:0000269|PubMed:9384611}. Lysosome lumen {ECO:0000269|PubMed:9384611}. Cell membrane {ECO:0000269|PubMed:9384611}. Cytoplasmic vesicle {ECO:0000269|PubMed:9384611}. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.
Tissue Specificity Highly expressed in kidney, epididymis, followed by brain, spinal cord and weakly expressed in adrenal, heart, liver, lung and spleen. {ECO:0000269|PubMed:9384611}.
Top Pathways Lysosome, Sphingolipid metabolism, Other glycan degradation

HER2 antibody - 70R-37512 from Fitzgerald

Prices $225.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Neu, Monoclonal Antibody - MBS530461 from MyBioSource

Prices $570.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B5
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