Neu1

Gene Symbol Neu1
Entrez Gene 18010
Alt Symbol AA407268, AA407316, Aglp, Apl, Bat-7, Bat7, G9, Map-2, Neu, Neu-1
Species Mouse
Gene Type protein-coding
Description neuraminidase 1
Other Description G9 sialidase|HLA-B-associated transcript 7|N-acetyl-alpha-neuraminidase 1|lysosomal sialidase|sialidase 1|sialidase-1
Swissprots O55220 Q99KG9 O35657
Accessions AAC84167 CAD91185 EDL26719 EDL26720 EDL26721 O35657 AK077444 AK138332 AK145680 BAE26586 AK148229 AK182863 AK186151 AK186636 AK187229 AK187684 AK189610 AK190751 AK193377 AK200662 AK200961 AK210577 AK212019 BC004666 AAH04666 BY281600 U93702 AAC53536 Y11412 CAA72215 NM_010893 NP_035023
Function Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. {ECO:0000269|PubMed:9363440, ECO:0000269|PubMed:9384611}.
Subcellular Location Lysosome membrane {ECO:0000269|PubMed:9384611}; Peripheral membrane protein {ECO:0000269|PubMed:9384611}; Lumenal side {ECO:0000269|PubMed:9384611}. Lysosome lumen {ECO:0000269|PubMed:9384611}. Cell membrane {ECO:0000269|PubMed:9384611}. Cytoplasmic vesicle {ECO:0000269|PubMed:9384611}. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.
Tissue Specificity Highly expressed in kidney, epididymis, followed by brain, spinal cord and weakly expressed in adrenal, heart, liver, lung and spleen. {ECO:0000269|PubMed:9384611}.
Top Pathways Lysosome, Sphingolipid metabolism, Other glycan degradation

Mouse NEU1 ORF clone(NM_010893.3) - CDCH391703 from Creative Biomart

Species Mouse
Accession NM_010893.3

Mouse Neu1 ORF Clone(NM_010893.3) - CDCL170834 from Creative Biomart

Species Mouse
Accession NM_010893.3

Mouse Neu1 ORF Clone(NM_010893.3) - CDCR249795 from Creative Biomart

Species Mouse
Accession NM_010893.3

Mouse Neu1 ORF Clone(NM_010893.3) - CDCR249796 from Creative Biomart

Species Mouse
Accession NM_010893.3

Mouse Neu1 ORF Clone(NM_010893.3) - CDCR249795 from Creative biogene

Species Mouse
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