| Gene Symbol | Neu1 |
|---|---|
| Entrez Gene | 18010 |
| Alt Symbol | AA407268, AA407316, Aglp, Apl, Bat-7, Bat7, G9, Map-2, Neu, Neu-1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | neuraminidase 1 |
| Other Description | G9 sialidase|HLA-B-associated transcript 7|N-acetyl-alpha-neuraminidase 1|lysosomal sialidase|sialidase 1|sialidase-1 |
| Swissprots | O55220 Q99KG9 O35657 |
| Accessions | AAC84167 CAD91185 EDL26719 EDL26720 EDL26721 O35657 AK077444 AK138332 AK145680 BAE26586 AK148229 AK182863 AK186151 AK186636 AK187229 AK187684 AK189610 AK190751 AK193377 AK200662 AK200961 AK210577 AK212019 BC004666 AAH04666 BY281600 U93702 AAC53536 Y11412 CAA72215 NM_010893 NP_035023 |
| Function | Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. {ECO:0000269|PubMed:9363440, ECO:0000269|PubMed:9384611}. |
| Subcellular Location | Lysosome membrane {ECO:0000269|PubMed:9384611}; Peripheral membrane protein {ECO:0000269|PubMed:9384611}; Lumenal side {ECO:0000269|PubMed:9384611}. Lysosome lumen {ECO:0000269|PubMed:9384611}. Cell membrane {ECO:0000269|PubMed:9384611}. Cytoplasmic vesicle {ECO:0000269|PubMed:9384611}. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles. |
| Tissue Specificity | Highly expressed in kidney, epididymis, followed by brain, spinal cord and weakly expressed in adrenal, heart, liver, lung and spleen. {ECO:0000269|PubMed:9384611}. |
| Top Pathways | Lysosome, Sphingolipid metabolism, Other glycan degradation |