Gene Symbol | Nr1i3 |
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Entrez Gene | 12355 |
Alt Symbol | AA209988, AI551208, CAR, CAR-beta, Care2, ESTM32, MB67 |
Species | Mouse |
Gene Type | protein-coding |
Description | nuclear receptor subfamily 1, group I, member 3 |
Other Description | constitutive androstane receptor|constitutively transactivates RAREs|nuclear receptor subfamily 1 group I member 3|orphan nuclear receptor MB67 |
Swissprots | O35627 Q3V008 O35628 |
Accessions | EDL39125 EDL39126 EDL39127 O35627 AF009327 AAC53349 AF009328 AAC53350 AI132241 AK133515 BAE21697 AK149381 AK149430 BAE28870 BC025154 BC037645 AAH37645 BC089541 AAH89541 XM_006496628 XP_006496691 XM_006496629 XP_006496692 XM_006496630 XP_006496693 XM_006496631 XP_006496694 XM_006496632 XP_006496695 XM_011238743 XP_011237045 XM_011238744 XP_011237046 XR_373594 XR_373595 NM_001243062 NP_001229991 NM_001243063 NP_001229992 NM_009803 NP_033933 |
Function | Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus. Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Recruited to the cytoplasm by DNAJC7. |
Tissue Specificity | Predominantly expressed in liver. |
CAR1/2 CRISPR/Cas9 KO Plasmid (m) - sc-419458 from Santa Cruz Biotechnology
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CAR1/2 HDR Plasmid (m) - sc-419458-HDR from Santa Cruz Biotechnology
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CAR1/2 Double Nickase Plasmid (m) - sc-419458-NIC from Santa Cruz Biotechnology
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CAR1/2 Double Nickase Plasmid (m2) - sc-419458-NIC-2 from Santa Cruz Biotechnology
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CAR1/2 CRISPR Activation Plasmid (m) - sc-419458-ACT from Santa Cruz Biotechnology
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CAR1/2 CRISPR Activation Plasmid (m2) - sc-419458-ACT-2 from Santa Cruz Biotechnology
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CAR1/2 Lentiviral Activation Particles (m) - sc-419458-LAC from Santa Cruz Biotechnology
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CAR1/2 Lentiviral Activation Particles (m2) - sc-419458-LAC-2 from Santa Cruz Biotechnology
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CAR1/2 siRNA (m) - sc-43663 from Santa Cruz Biotechnology
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CAR1/2 shRNA Plasmid (m) - sc-43663-SH from Santa Cruz Biotechnology
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CAR1/2 shRNA (m) Lentiviral Particles - sc-43663-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN36654 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36654 from Sigma-Aldrich
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NR1I3 siRNA (Mouse) - CRM0501 from Cohesion Biosciences
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CAR1/2 CRISPR/Cas9 KO Plasmid (m2) - sc-419458-KO-2 from Santa Cruz Biotechnology
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CAR1/2 HDR Plasmid (m2) - sc-419458-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Mouse NR1I3 (NM_009803.5) - SHH354716 from Creative biogene
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NR1I3 shRNA Plasmid (Mouse) - CHM0501 from Cohesion Biosciences
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