EMD

Gene Symbol	EMD
Entrez Gene	2010
Alt Symbol	EDMD, LEMD5, STA
Species	Human
Gene Type	protein-coding
Description	emerin
Other Description	LEM domain containing 5
Swissprots	Q6FI02 P50402
Accessions	AAA92645 BAA10972 CAA60500 EAW72742 EAW72743 P50402 AM393723 CAL38599 BC000738 AAH00738 BT007401 AAP36065 CR536536 CAG38773 CX781694 X82434 CAA57817 NM_000117 NP_000108
Function	Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649}.
Subcellular Location	Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane. Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non- farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.
Tissue Specificity	Skeletal muscle, heart, colon, testis, ovary and pancreas.
Top Pathways	Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Emerin full length protein - ab112283 from Abcam Category Protein Source Wheat germ Species Human

Human Emerin peptide - ab40723 from Abcam Category Peptide

Human Emerin peptide - ab40724 from Abcam Category Peptide

Human Emerin protein fragment - ab152363 from Abcam Category Protein Source Wheat germ Species Human

EMD / Emerin Antibody Blocking Peptide - LS-E8262 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EMD / Emerin Antibody Blocking Peptide - LS-E30307 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

EMD / Emerin Antibody Blocking Peptide - LS-E23017 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Emerin Protein - H00002010-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Emerin Protein - H00002010-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Emerin Blocking Peptide - NBP1-76757PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

EMD-Antibody-C-term-Blocking-Peptide - BP6525b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Emerin Peptide - GTX85058-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Emerin - H00002010-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Emerin - H00002010-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Emerin - H00002010-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Emerin - H00002010-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Emerin Control Peptide - AP30313CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Emerin Peptide - 4031P from ProSci Category Peptide Species Human

EMD fusion protein - ag0236 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human EMD - EMD-28289TH from Creative Biomart Category Protein Source Wheat germ

Emerin - TP300643 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Emerin Recombinant Protein Antigen - NBP1-87692PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

EMD-Antibody-N-term-Blocking-Peptide - BP6525a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EMD Peptide, Human - M34GP04900H from Creative Peptides Category Peptide Source Synthetic. Species Human

Emerin peptide - orb13019 from Biorbyt Category Peptide Prices $170.00 Sizes 1 mg

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