EMD

Gene Symbol EMD
Entrez Gene 2010
Alt Symbol EDMD, LEMD5, STA
Species Human
Gene Type protein-coding
Description emerin
Other Description LEM domain containing 5
Swissprots Q6FI02 P50402
Accessions AAA92645 BAA10972 CAA60500 EAW72742 EAW72743 P50402 AM393723 CAL38599 BC000738 AAH00738 BT007401 AAP36065 CR536536 CAG38773 CX781694 X82434 CAA57817 NM_000117 NP_000108
Function Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649}.
Subcellular Location Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane. Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non- farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.
Tissue Specificity Skeletal muscle, heart, colon, testis, ovary and pancreas.
Top Pathways Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy

emerin CRISPR/Cas9 KO Plasmid (h) - sc-401048 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

emerin HDR Plasmid (h) - sc-401048-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

emerin Double Nickase Plasmid (h) - sc-401048-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

emerin Double Nickase Plasmid (h2) - sc-401048-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

emerin CRISPR Activation Plasmid (h) - sc-401048-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

emerin CRISPR Activation Plasmid (h2) - sc-401048-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

emerin Lentiviral Activation Particles (h) - sc-401048-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

emerin Lentiviral Activation Particles (h2) - sc-401048-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

emerin siRNA (h) - sc-35296 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

emerin shRNA Plasmid (h) - sc-35296-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

emerin shRNA (h) Lentiviral Particles - sc-35296-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Emerin RNAi - H00002010-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU032871 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7835 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7835 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02298 from Sigma-Aldrich

Category miRNA

EMD siRNA (Human) - CRH1391 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EMD - MBS8224584 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Emerin - MBS826811 from MyBioSource

Prices $255.00
Sizes 5 od
Species Reactivities Human

emerin CRISPR/Cas9 KO Plasmid (h2) - sc-401048-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

emerin HDR Plasmid (h2) - sc-401048-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human EMD (NM_000117.2) - SHH285401 from Creative biogene

Category siRNA
Species Reactivities Human

EMD shRNA Plasmid (Human) - CHH1391 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EMD miRNA 3'UTR clone - MiUTR3H-02729 from Creative biogene

Species Reactivities Human
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