Hif1a

Gene Symbol	Hif1a
Entrez Gene	15251
Alt Symbol	AA959795, HIF1alpha, MOP1, bHLHe78
Species	Mouse
Gene Type	protein-coding
Description	hypoxia inducible factor 1, alpha subunit
Other Description	ARNT-interacting protein|HIF-1-alpha|HIF1-alpha|hypoxia-inducible factor 1-alpha
Swissprots	Q9CYA8 Q61221 Q8R385 Q8C681 O08741 Q8CCB6 Q61664 O08993 Q61665 Q8CC19
Accessions	AAC52730 AAC53461 CAA70305 CAA70306 EDL36500 EDL36501 Q61221 AF003695 AAC53455 AK008499 AK017853 BAB30975 AK033471 BAC28305 AK034087 BAC28578 AK048798 AK076395 BAC36320 AK138944 BAE23829 AK150367 BAE29500 BC026139 AAH26139 BY725437 CO810618 CX241289 X95002 CAA64458 X95580 CAA64833 XM_006515477 XP_006515540 XM_006515478 XP_006515541 XM_011243996 XP_011242298 XM_011243997 XP_011242299 NM_010431 NP_034561
Function	Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15225651}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:15225651, ECO:0000269|PubMed:21546903}. Nucleus speckle {ECO:0000269|PubMed:21546903}. Note=Colocalizes with HIF3A isoform 2 in the nucleus and speckles (PubMed:21546903). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia. Colocalizes with SUMO1 in the nucleus, under hypoxia (By similarity). {ECO:0000250, ECO:0000269|PubMed:21546903}.
Tissue Specificity	Ubiquitous.
Top Pathways	Renal cell carcinoma, Central carbon metabolism in cancer, Choline metabolism in cancer, Proteoglycans in cancer, mTOR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Hypoxia Inducible Factor 1 Alpha (HIF1a), Mouse, ELISA Kit - SEA798Mu from ARP American Research Products Category ELISA Kit Prices $668.00 Sizes 96 t Sensitivity 0.051ng/mL Range 0.156-10ng/mL

Hypoxia-inducible factor 1-alpha, Hif1a, Mouse, ELISA Kit - E0798m from ARP American Research Products Category ELISA Kit Prices $576.00 Sizes 96 t Range 78-5000 pg/mL

Hypoxia-inducible factor 1_, HIF-1_, Mouse, ELISA Kit - CSB-E08541m from ARP American Research Products Category ELISA Kit Prices $565.00, $835.00, $837.00, $839.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.156 pg/ml Range 0.625 pg/ml-40 pg/ml

Hypoxia Inducible Factor 1 Alpha (HIF1a), Mouse, CLIA Kit - SCA798Mu from ARP American Research Products Category CLIA Kit Prices $864.00 Sizes 96 t Sensitivity 11.3pg/mL Range 31.2-2,000pg/mL

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) , ELISA Kit - MBS702590 from MyBioSource Category ELISA Kit Prices $250.00, $575.00, $835.00, $3,040.00, $5,755.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.156 pg/ml. Range 0.625 pg/ml-40 pg/ml.

Mouse hypoxia-inducible factor 1α,HIF-1α ELISA Kit - CSB-E08541m from Cusabio Category ELISA Kit Sensitivity 0.156 pg/ml Range 0.625 pg/ml-40 pg/ml

ELISA Kit for Hypoxia Inducible Factor 1 Alpha (HIF1a) - SEA798Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

CLIA Kit for Hypoxia Inducible Factor 1 Alpha (HIF1a) - SCA798Mu from Cloud-clone Category CLIA Kit Sensitivity The minimum detectable dose of this kit is typically less than 1.11pg/mL. Range 2.743-2000pg/mL The standard curve concentrations used for the ELISA's were 2000pg/mL, 666.67pg/mL, 222.22pg/mL, 74.07pg/mL, 24.691pg/mL, 8.23pg/mL, 2.743pg/mL

Mouse HIF-1Alpha(Hypoxia Inducible Factor 1 Alpha) ELISA Kit - E-EL-M0687 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 75 pg/mL Range 125~8000 pg/mL

Mouse Alpha-CTx (Alpha Crosslaps) CLIA Kit - E-CL-M0233 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 46.875pg/mL Range 78.125-5000pg/mL

Mouse HIF1a ELISA Kit - abx154139 from Abbexa Category ELISA Kit Sensitivity 0.065 ng/ml Range 0.156 ng/ml - 10 ng/ml

Mouse Hypoxia-inducible factor 1-alpha ELISA Kit - abx254669 from Abbexa Category ELISA Kit Range 125 pg/ml - 8000 pg/ml

Hypoxia Inducible Factor 1 Alpha (HIF1a), Mouse, ELISA Kit - DL-HIF1a-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 31.2-2,000 pg/mL

HIF-1 alpha ELISA Kit - ARG80969 from Arigo Biolaboratories Category ELISA Kit Sensitivity 100 pg/ml Range 125-8000 pg/ml

Mouse Hypoxia-inducible factor 1-alpha ELISA Kit - EKE51621 from Biomatik Category ELISA Kit Prices $662.40, $2,815.20, $5,299.20 Sizes 96 t, 5x96t, 10x96t Range 78-5000 pg/mL

Hif1α - EKM620 from Nordic BioSite Sensitivity 75pg/ml Range 125-8000pg/ml

Mouse Hif1a ELISA Kit - E056172 from Biobool Category ELISA Kit Sensitivity Typically less than 0.061ng/mL.

Mouse Hif1alpha ELISA Kit - E056179 from Biobool Category ELISA Kit Sensitivity < 75pg/ml

HIF1A ELISA Kit (Mouse) (OKEH03021) - OKEH03021 from Aviva Systems Biology Category ELISA Kit Prices $395.00 Sizes 96 wells Sensitivity 39 pg/mL Range 78 - 5,000 pg/mL

Mouse Hypoxia-inducible factor 1-alpha ELISA Kit - EK2255 from Signalway Antibody Category ELISA Kit Prices $579.00 Sizes 1x96t Range 78-5000 pg/mL

Mouse HIF1 alpha ELISA Kit - CEK2066 from Cohesion Biosciences Category ELISA Kit Prices $380.00 Sizes 96 t Sensitivity 60 pg/ml Range 125 pg/ml - 8000 pg/ml

Hypoxia Inducible Factor 1 Alpha (HIF1a), ELISA Kit - MBS453686 from MyBioSource Category ELISA Kit Prices $395.00, $520.00, $2,275.00, $4,420.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.058ng/mL Range 0.156-10ng/mL

Hypoxia Inducible Factor 1 Alpha (HIF1a) , ELISA Kit - MBS2087593 from MyBioSource Category ELISA Kit Prices $495.00, $745.00, $1,030.00, $4,250.00, $7,660.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.056ng/mL Range 0.156-10ng/mL

Hypoxia-inducible factor 1-alpha, ELISA Kit - MBS2881121 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 78-5000 pg/mL

Hypoxia-inducible factor 1-alpha, ELISA Kit - MBS9426100 from MyBioSource Category ELISA Kit Prices $540.00 Sizes 96 tests Range 78-5000 pg/mL

Search more