| Gene Symbol |
Hif1a
|
| Entrez Gene |
15251
|
| Alt Symbol |
AA959795, HIF1alpha, MOP1, bHLHe78
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
hypoxia inducible factor 1, alpha subunit
|
| Other Description |
ARNT-interacting protein|HIF-1-alpha|HIF1-alpha|hypoxia-inducible factor 1-alpha
|
| Swissprots |
Q9CYA8 Q61221 Q8R385 Q8C681 O08741 Q8CCB6 Q61664 O08993 Q61665 Q8CC19
|
| Accessions |
AAC52730 AAC53461 CAA70305 CAA70306 EDL36500 EDL36501 Q61221 AF003695 AAC53455 AK008499 AK017853 BAB30975 AK033471 BAC28305 AK034087 BAC28578 AK048798 AK076395 BAC36320 AK138944 BAE23829 AK150367 BAE29500 BC026139 AAH26139 BY725437 CO810618 CX241289 X95002 CAA64458 X95580 CAA64833 XM_006515477 XP_006515540 XM_006515478 XP_006515541 XM_011243996 XP_011242298 XM_011243997 XP_011242299 NM_010431 NP_034561
|
| Function |
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15225651}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:15225651, ECO:0000269|PubMed:21546903}. Nucleus speckle {ECO:0000269|PubMed:21546903}. Note=Colocalizes with HIF3A isoform 2 in the nucleus and speckles (PubMed:21546903). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia. Colocalizes with SUMO1 in the nucleus, under hypoxia (By similarity). {ECO:0000250, ECO:0000269|PubMed:21546903}.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Renal cell carcinoma, Central carbon metabolism in cancer, Choline metabolism in cancer, Proteoglycans in cancer, mTOR signaling pathway
|