Hif1a

Gene Symbol	Hif1a
Entrez Gene	15251
Alt Symbol	AA959795, HIF1alpha, MOP1, bHLHe78
Species	Mouse
Gene Type	protein-coding
Description	hypoxia inducible factor 1, alpha subunit
Other Description	ARNT-interacting protein|HIF-1-alpha|HIF1-alpha|hypoxia-inducible factor 1-alpha
Swissprots	Q9CYA8 Q61221 Q8R385 Q8C681 O08741 Q8CCB6 Q61664 O08993 Q61665 Q8CC19
Accessions	AAC52730 AAC53461 CAA70305 CAA70306 EDL36500 EDL36501 Q61221 AF003695 AAC53455 AK008499 AK017853 BAB30975 AK033471 BAC28305 AK034087 BAC28578 AK048798 AK076395 BAC36320 AK138944 BAE23829 AK150367 BAE29500 BC026139 AAH26139 BY725437 CO810618 CX241289 X95002 CAA64458 X95580 CAA64833 XM_006515477 XP_006515540 XM_006515478 XP_006515541 XM_011243996 XP_011242298 XM_011243997 XP_011242299 NM_010431 NP_034561
Function	Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15225651}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:15225651, ECO:0000269|PubMed:21546903}. Nucleus speckle {ECO:0000269|PubMed:21546903}. Note=Colocalizes with HIF3A isoform 2 in the nucleus and speckles (PubMed:21546903). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia. Colocalizes with SUMO1 in the nucleus, under hypoxia (By similarity). {ECO:0000250, ECO:0000269|PubMed:21546903}.
Tissue Specificity	Ubiquitous.
Top Pathways	Renal cell carcinoma, Central carbon metabolism in cancer, Choline metabolism in cancer, Proteoglycans in cancer, mTOR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HIF-1 alpha Antibody - NB100-479 from Novus Biologicals Prices $149.00, $349.00 Sizes 25 µl, 100 µl Host Rabbit Clonality Polyclonal

HIF-1 alpha Antibody [HRP] - NB100-479H from Novus Biologicals Prices $319.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

HIF-1 alpha Antibody [Biotin] - NB100-479B from Novus Biologicals Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

HIF-1 alpha Antibody [Alexa Fluor (R) 647] - NB100-479AF647 from Novus Biologicals Prices $329.00 Sizes 100 tests Host Rabbit Clonality Polyclonal

HIF-1 alpha Antibody [Alexa Fluor (R) 700] - NB100-479AF700 from Novus Biologicals Prices $339.00 Sizes 100 tests Host Rabbit Clonality Polyclonal

HIF-1 alpha Antibody [Alexa Fluor (R) 488] - NB100-479AF488 from Novus Biologicals Prices $359.00 Sizes 100 tests Host Rabbit Clonality Polyclonal

HIF-1 alpha Antibody [Alexa Fluor (R) 405] - NB100-479AF405 from Novus Biologicals Prices $329.00 Sizes 100 tests Host Rabbit Clonality Polyclonal

HIF-1 alpha Antibody [FITC] - NB100-479F from Novus Biologicals Prices $249.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

HIF-1 alpha Antibody [DyLight 405] - NB100-479V from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

HIF-1 alpha Antibody [DyLight 488] - NB100-479G from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

HIF-1 alpha Antibody [DyLight 550] - NB100-479R from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

HIF-1 alpha Antibody [DyLight 650] - NB100-479C from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Monoclonal Anti-HIF-1 α antibody produced in mouse - SAB5200017 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone ESEE122

HIF1 alpha Antibody (OASE00129) - OASE00129 from Aviva Systems Biology Prices $140.00 Sizes 25 µg Host Mouse Clonality Monoclonal Clone ESEE122

HIF1 alpha Antibody (OASE00130) - OASE00130 from Aviva Systems Biology Prices $315.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone ESEE122

HIF1 alpha antibody (Biotin) - orb147874 from Biorbyt Prices $451.00 Sizes 100 μg Host Mouse Clonality Monoclonal

HIF1a Antibody - abx103438 from Abbexa Host Rabbit Clonality Polyclonal

HIF1A / HIF1 alpha (329-530) antibody - AM20057PU-N from Acris Antibodies Prices $310.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone ESEE122

HIF1A / HIF1 alpha (329-530) antibody - AM20057PU-S from Acris Antibodies Prices $205.00 Sizes 25 µg Host Mouse Clonality Monoclonal Clone ESEE122

HIF1A / HIF1 alpha antibody - PAB12138 from Acris Antibodies Prices $500.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Hypoxia Inducible Factor 1 Alpha (HIF1a) - 20-3190 from ARP American Research Products Prices $289.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

HIF 1 alpha Antibody - SMC-184C from StressMarq Bioscience Prices $108.00 Sizes 25 µg Host Mouse Clonality Monoclonal Clone ESEE122

HIF 1 alpha Antibody - SMC-184D from StressMarq Bioscience Prices $263.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone ESEE122

HIF1a, Polyclonal Antibody - MBS448067 from MyBioSource Prices $410.00 Sizes 600 µg Host Goat Clonality Polyclonal

HIF1Alpha, Polyclonal Antibody - MBS641565 from MyBioSource Prices $550.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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