CACNA1A

Gene Symbol	CACNA1A
Entrez Gene	773
Alt Symbol	APCA, BI, CACNL1A4, CAV2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6
Species	Human
Gene Type	protein-coding
Description	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Other Description	brain calcium channel 1|brain calcium channel I|calcium channel, L type, alpha-1 polypeptide|voltage-dependent P/Q-type calcium channel subunit alpha-1A|voltage-gated calcium channel subunit alpha Cav2.1
Swissprots	J3KP41 P78510 Q16290 Q99793 Q9UDC4 Q99790 O00555 Q9NS88 Q99791 Q99792 P78511 Q92690
Accessions	AAC26839 AAD38386 AAF03935 EAW84361 EAW84362 EAW84363 EAW84364 EAW84365 EAW84366 O00555 AB035726 BAA94765 AB035727 BAA94766 AF004883 AAB61612 AF004884 AAB61613 AF100774 AAC77460 BC028611 BQ340521 EU016197 ABV80232 FJ040507 ACH89974 S76537 AAB33068 U06702 U79663 AAB49674 U79664 AAB49675 U79665 AAB49676 U79666 AAB64179 U79667 AAB49677 U79668 AAB49678 X99897 CAA68172 NM_000068 NP_000059 NM_001127221 NP_001120693 NM_001127222 NP_001120694 NM_001174080 NP_001167551 NM_023035 NP_075461
Function	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
Subcellular Location	Membrane; Multi-pass membrane protein.
Tissue Specificity	Brain specific; mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P- type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells. {ECO:0000269|PubMed:1335101}.
Top Pathways	Retrograde endocannabinoid signaling, Morphine addiction, Nicotine addiction, Long-term depression, Dopaminergic synapse

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat CACNA1A / Cav2.1 ELISA Kit (Sandwich ELISA) - LS-F10978 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

Human CACNA1A / Cav2.1 ELISA Kit (Sandwich ELISA) - LS-F10977 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Anti-paternal cytotoxic antibody (APCA), Human, ELISA Kit - E01A2105 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Neuron-specific calcium-binding protein hippocalcin (HPCA), Human, ELISA Kit - E01N0527 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A), Human, ELISA Kit - E01V0055 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Voltage-dependent P/Q-type calcium channel subunit alpha-1A, CACNA1A, Human, ELISA Kit - E1344h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, ELISA Kit - MBS9340828 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.625ng/ml-20ng/ml.

Voltage-dependent P/Q-type calcium channel subunit Alpha 1A (CACNA1A), ELISA Kit - MBS7223860 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A), ELISA Kit - MBS7228163 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A), ELISA Kit - MBS7200774 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A), ELISA Kit - MBS7249937 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A), ELISA Kit - MBS7203115 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A), ELISA Kit - MBS7252557 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A), ELISA Kit - MBS7212139 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A), ELISA Kit - MBS7248074 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A), ELISA Kit - MBS7231714 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A), ELISA Kit - MBS7203323 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rabbit CACNA1A / Cav2.1 ELISA Kit - LS-F16940 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range To be determined

Mouse CACNA1A / Cav2.1 ELISA Kit (Custom ELISA) - LS-F16941 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Chicken CACNA1A / Cav2.1 ELISA Kit (Custom ELISA) - LS-F16942 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human Voltage-dependent P/Q-type calcium channel subunit alpha-1A ELISA Kit - abx250796 from Abbexa Category ELISA Kit Sensitivity 46.875 pg/ml Range 78.125 pg/ml - 5000 pg/ml

Human Voltage-dependent P/Q-type calcium channel subunit alpha-1A ELISA Kit - EKE53876 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.078 ng/mL Range 0.156-10 ng/mL

CACNA1A - EKH3024 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

CACNA1A ELISA Kit (Human) : 96 Wells (OKEH00960) - OKEH00960 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.078 ng/mL Range 0.156 - 10 ng/mL

Human CACNA1A ELISA Kit - E006043 from Biobool Category ELISA Kit Sensitivity 0.1ng/ml.

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