| Gene Symbol |
CACNA1A
|
| Entrez Gene |
773
|
| Alt Symbol |
APCA, BI, CACNL1A4, CAV2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
|
| Other Description |
brain calcium channel 1|brain calcium channel I|calcium channel, L type, alpha-1 polypeptide|voltage-dependent P/Q-type calcium channel subunit alpha-1A|voltage-gated calcium channel subunit alpha Cav2.1
|
| Swissprots |
J3KP41 P78510 Q16290 Q99793 Q9UDC4 Q99790 O00555 Q9NS88 Q99791 Q99792 P78511 Q92690
|
| Accessions |
AAC26839 AAD38386 AAF03935 EAW84361 EAW84362 EAW84363 EAW84364 EAW84365 EAW84366 O00555 AB035726 BAA94765 AB035727 BAA94766 AF004883 AAB61612 AF004884 AAB61613 AF100774 AAC77460 BC028611 BQ340521 EU016197 ABV80232 FJ040507 ACH89974 S76537 AAB33068 U06702 U79663 AAB49674 U79664 AAB49675 U79665 AAB49676 U79666 AAB64179 U79667 AAB49677 U79668 AAB49678 X99897 CAA68172 NM_000068 NP_000059 NM_001127221 NP_001120693 NM_001127222 NP_001120694 NM_001174080 NP_001167551 NM_023035 NP_075461
|
| Function |
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Brain specific; mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P- type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells. {ECO:0000269|PubMed:1335101}.
|
| Top Pathways |
Retrograde endocannabinoid signaling, Morphine addiction, Nicotine addiction, Long-term depression, Dopaminergic synapse
|