CACNA1A
| Gene Symbol | CACNA1A |
|---|---|
| Entrez Gene | 773 |
| Alt Symbol | APCA, BI, CACNL1A4, CAV2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit |
| Other Description | brain calcium channel 1|brain calcium channel I|calcium channel, L type, alpha-1 polypeptide|voltage-dependent P/Q-type calcium channel subunit alpha-1A|voltage-gated calcium channel subunit alpha Cav2.1 |
| Swissprots | J3KP41 P78510 Q16290 Q99793 Q9UDC4 Q99790 O00555 Q9NS88 Q99791 Q99792 P78511 Q92690 |
| Accessions | AAC26839 AAD38386 AAF03935 EAW84361 EAW84362 EAW84363 EAW84364 EAW84365 EAW84366 O00555 AB035726 BAA94765 AB035727 BAA94766 AF004883 AAB61612 AF004884 AAB61613 AF100774 AAC77460 BC028611 BQ340521 EU016197 ABV80232 FJ040507 ACH89974 S76537 AAB33068 U06702 U79663 AAB49674 U79664 AAB49675 U79665 AAB49676 U79666 AAB64179 U79667 AAB49677 U79668 AAB49678 X99897 CAA68172 NM_000068 NP_000059 NM_001127221 NP_001120693 NM_001127222 NP_001120694 NM_001174080 NP_001167551 NM_023035 NP_075461 |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA). |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Brain specific; mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P- type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells. {ECO:0000269|PubMed:1335101}. |
| Top Pathways | Retrograde endocannabinoid signaling, Morphine addiction, Nicotine addiction, Long-term depression, Dopaminergic synapse |
P/Q-type Ca ++ CP α1A CRISPR/Cas9 KO Plasmid (h) - sc-404267 from Santa Cruz Biotechnology
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P/Q-type Ca ++ CP α1A HDR Plasmid (h) - sc-404267-HDR from Santa Cruz Biotechnology
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P/Q-type Ca ++ CP α1A Double Nickase Plasmid (h) - sc-404267-NIC from Santa Cruz Biotechnology
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P/Q-type Ca ++ CP α1A Double Nickase Plasmid (h2) - sc-404267-NIC-2 from Santa Cruz Biotechnology
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P/Q-type Ca ++ CP α1A CRISPR Activation Plasmid (h) - sc-404267-ACT from Santa Cruz Biotechnology
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P/Q-type Ca ++ CP α1A CRISPR Activation Plasmid (h2) - sc-404267-ACT-2 from Santa Cruz Biotechnology
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P/Q-type Ca ++ CP α1A Lentiviral Activation Particles (h) - sc-404267-LAC from Santa Cruz Biotechnology
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P/Q-type Ca ++ CP α1A Lentiviral Activation Particles (h2) - sc-404267-LAC-2 from Santa Cruz Biotechnology
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P/Q-type Ca ++ CP α1A siRNA (h) - sc-42700 from Santa Cruz Biotechnology
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P/Q-type Ca ++ CP α1A shRNA Plasmid (h) - sc-42700-SH from Santa Cruz Biotechnology
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P/Q-type Ca ++ CP α1A shRNA (h) Lentiviral Particles - sc-42700-V from Santa Cruz Biotechnology
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CACNA1A RNAi - H00000773-R01 from Novus Biologicals
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CACNA1A RNAi - H00000773-R02 from Novus Biologicals
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MISSION® esiRNA - EHU063741 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1915 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1915 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09779 from Sigma-Aldrich
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CACNA1A siRNA (Human) - CRH0538 from Cohesion Biosciences
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CACNA1A - MBS8220031 from MyBioSource
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shRNA set against Human CACNA1A (NM_000068.3) - SHH253249 from Creative biogene
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shRNA set against Human CACNA1A(NM_023035.2) - SHG122653 from Creative biogene
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shRNA set against Human CACNA1A(NM_000068.3) - SHG122707 from Creative biogene
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Human CACNA1A siRNA - orb261040 from Biorbyt
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CACNA1A shRNA Plasmid (Human) - CHH0538 from Cohesion Biosciences
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CACNA1A miRNA 3'UTR clone - MiUTR1H-01579 from Creative biogene
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