PCNA

Gene Symbol	PCNA
Entrez Gene	5111
Alt Symbol	ATLD2
Species	Human
Gene Type	protein-coding
Description	proliferating cell nuclear antigen
Other Description	DNA polymerase delta auxiliary protein|cyclin
Swissprots	D3DW02 B2R897 P12004
Accessions	AAA60040 AAM78556 AAP58729 AAP58730 AAP58731 AAP58732 EAX10428 EAX10429 EAX10430 P12004 AK300558 BAG62264 AK311014 AK313286 BAG36094 BC000491 AAH00491 BC062439 AAH62439 BG612192 BU626265 CB990423 CR536501 CAG38740 CR541799 CAG46598 D28458 BAA05824 DQ891403 ABM82329 DQ894581 ABM85507 M15796 AAA35736 NM_002592 NP_002583 NM_182649 NP_872590
Function	Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. {ECO:0000269|PubMed:18719106
Subcellular Location	Nucleus {ECO:0000269|PubMed:24115439}. Note=Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
Top Pathways	DNA replication, Mismatch repair, Cell cycle, Base excision repair, Nucleotide excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Total PCNA Sandwich ELISA Kit - 14513 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PCNA Human SimpleStep ELISA™ Kit - ab196270 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity 0.103 ng/ml Range 50 ng/ml - 0.78 ng/ml

Human PCNA / Cyclin ELISA Kit - LS-F4202 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.123 ng/ml Range 0.313 - 20 ng/ml

Mouse PCNA ELISA Kit (Sandwich ELISA) - LS-F12273 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Rabbit anti-PCNA Antibody, Affinity Purified - PLA0079 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Rabbit anti-PCNA Antibody, Affinity Purified - PLA0080 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Human PCNA ELISA Kit - abx054747 from Abbexa Category ELISA Kit

Human PCNA ELISA Kit - abx152659 from Abbexa Category ELISA Kit Sensitivity 0.123 ng/ml Range 0.313 ng/ml - 20 ng/ml

Proliferating Cell Nuclear Antigen, PCNA, Human, ELISA Kit - E-EL-H2399 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Proliferating cell nuclear antigen (PCNA) antibody, Human, ELISA Kit - CSB-E08496h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Proliferating cell nuclear antigen (PCNA), Human, ELISA Kit - CSB-EL017621HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Proliferating Cell Nuclear Antigen (PCNA), Human, ELISA Kit - SEA591Hu from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.123ng/mL Range 0.312-20ng/mL

Proliferating Cell Nuclear Antigen Antibody, PCNA, Human, ELISA Kit - YHB2452Hu from ARP American Research Products Category ELISA Kit

ProlifeRating Cell Nuclear Antigen, Human, ELISA Kit - E01P0067 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 1.0-25ng/ml

Proliferating cell nuclear antigen, PCNA, Human, ELISA Kit - E0591h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Proliferating Cell Nuclear Antigen, PCNA, Mouse, ELISA Kit - E-EL-M0951 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Proliferating Cell Nuclear Antigen, PCNA, Rat, ELISA Kit - E-EL-R0782 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Proliferating Cell Nuclear Antigen, PCNA, Rabbit, ELISA Kit - E-EL-RB2132 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Proliferating Cell Nuclear Antigen, PCNA, Chicken, ELISA Kit - E-EL-Ch2029 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Proliferating Cell Nuclear Antigen, PCNA, Porcine, ELISA Kit - E-EL-P1840 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Proliferating Cell Nuclear Antigen, PCNA, Guinea Pig, ELISA Kit - E-EL-GP0467 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Proliferating Cell Nuclear Antigen, PCNA, Monkey, ELISA Kit - E-EL-MK2056 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

PCNA (Human) IP-WB Antibody Pair - H00005111-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Custom Human PCNA ELISA - ELH-PCNA from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human PCNA ELISA Kit - HP0074 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

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