PCNA

Gene Symbol	PCNA
Entrez Gene	5111
Alt Symbol	ATLD2
Species	Human
Gene Type	protein-coding
Description	proliferating cell nuclear antigen
Other Description	DNA polymerase delta auxiliary protein|cyclin
Swissprots	D3DW02 B2R897 P12004
Accessions	AAA60040 AAM78556 AAP58729 AAP58730 AAP58731 AAP58732 EAX10428 EAX10429 EAX10430 P12004 AK300558 BAG62264 AK311014 AK313286 BAG36094 BC000491 AAH00491 BC062439 AAH62439 BG612192 BU626265 CB990423 CR536501 CAG38740 CR541799 CAG46598 D28458 BAA05824 DQ891403 ABM82329 DQ894581 ABM85507 M15796 AAA35736 NM_002592 NP_002583 NM_182649 NP_872590
Function	Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. {ECO:0000269|PubMed:18719106
Subcellular Location	Nucleus {ECO:0000269|PubMed:24115439}. Note=Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
Top Pathways	DNA replication, Mismatch repair, Cell cycle, Base excision repair, Nucleotide excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PCNA full length protein - ab172197 from Abcam Category Protein Source E. coli Species Human

Human PCNA full length protein - ab85651 from Abcam Category Protein Source E. coli Species Human

Human PCNA peptide - ab18602 from Abcam Category Peptide Species Human

PCNA peptide - ab2427 from Abcam Category Peptide

PCNA Antibody Blocking Peptide - LS-E7136 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PCNA Antibody Blocking Peptide - LS-E7137 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PCNA Antibody Blocking Peptide - LS-E27946 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PCNA Antibody Blocking Peptide - LS-E27947 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PCNA Protein - H00005111-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PCNA Partial Recombinant Protein - H00005111-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PCNA Protein - NBC1-18428 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

PCNA Protein - NBP1-99917 from Novus Biologicals Category Protein Prices $429.00 Sizes 5 µg Species Human

PCNA-Antibody-Center-Blocking-Peptide - BP2835c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PCNA-Antibody-C-term-Blocking-Peptide - BP2835b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PCNA peptide - GTX22427 from GeneTex Category Peptide Prices $179.00 Sizes 500 μl Species Human

PCNA Protein (OPPA01219) - OPPA01219 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Sf9 Insect Cells

PCNA Protein (OPPA01753) - OPPA01753 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

PCNA Protein (OPPA01981) - OPPA01981 from Aviva Systems Biology Category Protein Prices $315.00 Sizes 2 µg Source E. Coli

Human PCNA protein - orb78501 from Biorbyt Category Protein Prices $255.00, $391.00, $519.00 Sizes 10 μg, 50 μg, 100 μg Species Human

Human PCNA protein (His Tag) - orb139453 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

PCNA Immunizing peptide - orb66423 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

PCNA peptide - orb217722 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey, Cat

PCNA Blocking Peptide - 33R-5220 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PCNA Blocking Peptide - 33R-10719 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

PCNA protein - 30R-2724 from Fitzgerald Category Protein Prices $380.00 Sizes 5 µg Source Sf-9 insect cells Species Human

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