PCNA

Gene Symbol	PCNA
Entrez Gene	5111
Alt Symbol	ATLD2
Species	Human
Gene Type	protein-coding
Description	proliferating cell nuclear antigen
Other Description	DNA polymerase delta auxiliary protein|cyclin
Swissprots	D3DW02 B2R897 P12004
Accessions	AAA60040 AAM78556 AAP58729 AAP58730 AAP58731 AAP58732 EAX10428 EAX10429 EAX10430 P12004 AK300558 BAG62264 AK311014 AK313286 BAG36094 BC000491 AAH00491 BC062439 AAH62439 BG612192 BU626265 CB990423 CR536501 CAG38740 CR541799 CAG46598 D28458 BAA05824 DQ891403 ABM82329 DQ894581 ABM85507 M15796 AAA35736 NM_002592 NP_002583 NM_182649 NP_872590
Function	Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. {ECO:0000269|PubMed:18719106
Subcellular Location	Nucleus {ECO:0000269|PubMed:24115439}. Note=Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
Top Pathways	DNA replication, Mismatch repair, Cell cycle, Base excision repair, Nucleotide excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PCNA-Over-expression-Lysate - LY11123a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

PCNA overexpression lysate - LY400929 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PCNA overexpression lysate - LY405433 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PCNA overexpression lysate - LY430596 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PCNA 293 Cell Lysate - 400874 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PCNA Overexpression Lysate (Native) - NBL1-14184 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PCNA (h): 293T Lysate - sc-159920 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

PCNA (h2): 293T Lysate - sc-170834 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

PCNA Over-expression Lysate Product - GWB-D24EAC from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human PCNA Insect Cell Lysate (WB positive control) - 12131-H07BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human PCNA Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175116 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

PCNA Overexpression Lysate (Native) - NBP2-04828 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PCNA Overexpression Lysate (Native) - NBP2-10057 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PCNA Overexpression Lysate (Denatured) - H00005111-T02 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human PCNA Knockdown Stable Cell Line - CSC-DC011452 from Creative biogene Category Cell Line Species Human

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