| Gene Symbol | BCL2L2 |
|---|---|
| Entrez Gene | 599 |
| Alt Symbol | BCL-W, BCL2-L-2, BCLW, PPP1R51 |
| Species | Human |
| Gene Type | protein-coding |
| Description | BCL2-like 2 |
| Other Description | apoptosis regulator BCL-W|bcl-2-like protein 2|protein phosphatase 1, regulatory subunit 51 |
| Swissprots | A8K0F4 Q5U0H4 Q2M3U0 Q92843 |
| Accessions | EAW66169 Q92843 AA524030 AA741032 AK289519 BAF82208 BC021198 AAH21198 BC104789 AAI04790 BC113522 AAI13523 BP216712 BQ001111 BQ359913 BT019549 AAV38356 D87461 BAA19666 DA196433 DA288957 DA451936 HQ258092 ADR82846 U59747 AAB09055 NM_001199839 NP_001186768 NM_004050 NP_004041 |
| Function | Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. {ECO:0000269|PubMed:8761287}. |
| Subcellular Location | Mitochondrion membrane {ECO:0000269|PubMed:11423909, ECO:0000269|PubMed:12952938}; Peripheral membrane protein {ECO:0000269|PubMed:11423909, ECO:0000269|PubMed:12952938}. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane. |
| Tissue Specificity | Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. {ECO:0000269|PubMed:11423909}. |
| Top Pathways | MicroRNAs in cancer |