BCL2L2

Gene Symbol BCL2L2
Entrez Gene 599
Alt Symbol BCL-W, BCL2-L-2, BCLW, PPP1R51
Species Human
Gene Type protein-coding
Description BCL2-like 2
Other Description apoptosis regulator BCL-W|bcl-2-like protein 2|protein phosphatase 1, regulatory subunit 51
Swissprots A8K0F4 Q5U0H4 Q2M3U0 Q92843
Accessions EAW66169 Q92843 AA524030 AA741032 AK289519 BAF82208 BC021198 AAH21198 BC104789 AAI04790 BC113522 AAI13523 BP216712 BQ001111 BQ359913 BT019549 AAV38356 D87461 BAA19666 DA196433 DA288957 DA451936 HQ258092 ADR82846 U59747 AAB09055 NM_001199839 NP_001186768 NM_004050 NP_004041
Function Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. {ECO:0000269|PubMed:8761287}.
Subcellular Location Mitochondrion membrane {ECO:0000269|PubMed:11423909, ECO:0000269|PubMed:12952938}; Peripheral membrane protein {ECO:0000269|PubMed:11423909, ECO:0000269|PubMed:12952938}. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.
Tissue Specificity Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. {ECO:0000269|PubMed:11423909}.
Top Pathways MicroRNAs in cancer

Bcl-w CRISPR/Cas9 KO Plasmid (h) - sc-402639 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bcl-w HDR Plasmid (h) - sc-402639-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bcl-w Double Nickase Plasmid (h) - sc-402639-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bcl-w Double Nickase Plasmid (h2) - sc-402639-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bcl-w CRISPR Activation Plasmid (h) - sc-402639-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bcl-w CRISPR Activation Plasmid (h2) - sc-402639-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bcl-w Lentiviral Activation Particles (h) - sc-402639-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bcl-w Lentiviral Activation Particles (h2) - sc-402639-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bcl-w siRNA (h) - sc-37293 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Bcl-w shRNA Plasmid (h) - sc-37293-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Bcl-w shRNA (h) Lentiviral Particles - sc-37293-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU058421 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3914 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3914 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

BCL2L2 siRNA (Human) - CRH0412 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BCL-W/BCL2L2 RNAi - H00000599-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

BCL2L2 - MBS8238239 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human BCL2L2 (NM_004050.4) - SHH245994 from Creative biogene

Category siRNA
Species Reactivities Human

Human BCL2L2 siRNA - orb260914 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BCL2L2 shRNA Plasmid (Human) - CHH0412 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

BCL2L2 miRNA 3'UTR clone - MiUTR4H-TG00754 from Creative biogene

Species Reactivities Human
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