FN1

Gene Symbol FN1
Entrez Gene 2335
Alt Symbol CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF
Species Human
Gene Type protein-coding
Description fibronectin 1
Other Description cold-insoluble globulin|fibronectin|migration-stimulating factor
Swissprots Q86T27 Q6MZU5 Q68DT4 Q8IVI8 Q6MZS0 Q6LDP6 Q9H1B8 Q7Z391 Q68DP9 Q585T2 B7ZLF0 O95610 O95609 Q96KP7 Q9HAP3 Q6N0A6 Q14312 Q14325 Q68DP8 Q96KP9 Q96KP8 Q14326 E9PE77 Q59EH1 Q60FE4 Q9UMK2 Q17RV7 P02751 Q564H7 Q6N025 E9PG29
Accessions AAA52461 AAA53376 AAA58483 AAX76513 AAY24063 CAB52436 CAB52437 EAW70530 EAW70531 EAW70532 EAW70533 EAW70534 EAW70535 EAW70536 EAW70537 EAW70538 EAW70539 EAW70540 EAW70541 EAW70542 EAW70543 EAW70544 EAW70545 EAW70546 EAW70547 EAW70548 P02751 AB191261 BAD52437 AB209287 BAD92524 AB209840 BAD93077 AF130095 AAG35520 AF312399 AAG30571 AI033037 AJ276395 CAC20427 AJ320525 CAC86914 AJ320526 CAC86915 AJ320527 CAC86916 AJ535086 CAD59389 AJ849445 CAH60958 AK026737 AK094153 AK297733 BAG60083 AK300216 BAG61984 AK300246 BAG62013 AK300458 BAG62178 AK316350 BAH14721 AL832202 CAD91166 AL832771 BC005858 AAH05858 BC016875 AAH16875 BC078656 BC100030 BC117176 AAI17177 BC143754 AAI43755 BC143763 AAI43764 BQ005645 BT006856 AAP35502 BX537590 CAD97791 BX538017 CAD97964 BX538018 CAD97965 BX538045 CAD97984 BX640608 CAE45714 BX640638 CAE45786 BX640731 CAE45847 BX640802 CAE45885 BX640803 BX640875 CAE45932 BX640920 CAE45958 BX640999 CAE46002 BX641150 BX649182 CAE46200 CA422234 CR749281 CAH18136 CR749316 CAH18171 CR749317 CAH18172 CR749666 CAH18457 CR936623 CAI56766 DA851446 EF550130 ABR68534 EF550131 ABR68535 EF550132 ABR68536 EF550133 ABR68537 EF550134 ABR68538 EF550135 ABR68539 EU831936 ACE87377 EU832031 ACE86693 M10905 AAA52462 M14059 AAA52463 M14060 AAA52464 M27589 AAA52465 M27590 AAA52466 U41724 AAD00013 U41850 AAD00014 U42404 AAD00015 U42455 AAD09448 U42456 AAD09449 U42457 AAD04751 U42458 AAD09450 U42592 AAD00017 U42593 AAD00018 U42594 AAD00019 U60067 AAD11500 U60068 AAD10853 X02761 CAA26536 XM_005246397 XP_005246454 XM_005246398 XP_005246455 XM_005246399 XP_005246456 XM_005246400 XP_005246457 XM_005246401 XP_005246458 XM_005246402 XP_005246459 XM_005246403 XP_005246460 XM_005246404 XP_005246461 XM_005246405 XP_005246462 XM_005246406 XP_005246463 XM_005246407 XP_005246464 XM_005246408 XP_005246465 XM_005246409 XP_005246466 XM_005246410 XP_005246467 XM_005246411 XP_005246468 XM_005246412 XP_005246469 XM_005246413 XP_005246470 XM_005246414 XP_005246471 XM_005246415 XP_005246472 XM_005246416 XP_005246473 XM_005246417 XP_005246474 NM_001306129 NP_001293058 NM_001306130 NP_001293059 NM_001306131 NP_001293060 NM_001306132 NP_001293061 NM_002026 NP_002017 NM_054034 NP_473375 NM_212474 NP_997639 NM_212476 NP_997641 NM_212478 NP_997643 NM_212482 NP_997647 NM_212475
Function Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.
Subcellular Location Secreted, extracellular space, extracellular matrix.
Tissue Specificity Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine. {ECO:0000269|PubMed:17614963, ECO:0000269|PubMed:3584091}.
Top Pathways Proteoglycans in cancer, Focal adhesion, PI3K-Akt signaling pathway, Amoebiasis, Bacterial invasion of epithelial cells

Fibronectin (A-11) - sc-271098 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fibronectin (A-11): sc-271098. Western blot analysis of Fibronectin expression in HT-1080 (A) and Hep G2 (B) whole cell lysates.

Fibronectin (617) - sc-81769 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fibronectin (617): sc-81769. Western blot analysis of Fibronectin expression in U-87 MG whole cell lysate.

Fibronectin (C-20) - sc-6952 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Fibronectin (C-20): sc-6952. Western blot analysis of Fibronectin expression in CCD-1064Sk (A) and NIH/3T3 (B) whole cell lysates and human platelet extract (C).

Fibronectin (C6F10) - sc-73611 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fibronectin (C6F10): sc-73611. Western blot analysis of Fibronectin expression in U-87 MG (A) and HT-1080 (B) whole cell lysates and human platelet extract (C).

Fibronectin (EP5) - sc-8422 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fibronectin (EP5): sc-8422. Western blot analysis of Fibronectin expression in 3611-RF (A) and NIH/3T3 (B) whole cell lysates.

Fibronectin (Fn-3) - sc-53285 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fibronectin (Fn-3): sc-53285. Western blot analysis of Fibronectin expression in Hep G2 (A), CCD-1064Sk (B) whole cell lysates and human platelet extract (C).

Fibronectin (Fn-4) - sc-53286 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Fibronectin expression in Hep G2 whole cell lysate immunoprecipitated with Fibronectin (Fn-4): sc-53286 and detected with Fibronectin (Fn-3): sc-53285.

Fibronectin (IST-1) - sc-59824 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fibronectin (IST-1): sc-59824. Western blot analysis of Fibronectin expression in U-87 MG (A), HT-1080 (B) whole cell lysates and human platelet extract (C).

Fibronectin (N-20) - sc-6953 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Fibronectin (N-20): sc-6953. Western blot analysis of Fibronectin expression in human platelet extract.

Fibronectin (P1F11) - sc-18826 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fibronectin (P1F11): sc-18826. Western blot analysis of Fibronectin expression in CCD-1064Sk whole cell lysate.

Fibronectin (IST-9) - sc-59826 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fibronectin (IST-9): sc-59826. Western blot analysis of Fibronectin expression in Hep G2 (A) and HT-1080 (B) whole cell lysates.

Fibronectin (P1H11) - sc-18825 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fibronectin (P1H11): sc-18825. Immunofluorescence staining of methanol-fixed Hep G2 cells showing cytoplasmic and extracellular localization.

Fibronectin (TV-1) - sc-69682 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fibronectin (TV-1): sc-69682. Western blot analysis of Fibronectin expression in Hep G2 (A), CCD-1064Sk (B) whole cell lysates and human platelet extract (C) .

Fibronectin (P5F3) - sc-18827 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fibronectin (P5F3): sc-18827. Immunofluorescence staining of methanol-fixed Hep G2 cells showing cytoplasmic and extracellular staining.

Fibronectin (H-300) - sc-9068 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Fibronectin (H-300): sc-9068. Western blot analysis of Fibronectin expression in Hep G2 (A) and NCI-H929 (B) whole cell lysates.

Fibronectin (616) - sc-81767 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fibronectin (616): sc-81767. Western blot analysis of Fibronectin expression in human platelet extract (A) and HT-1080 whole cell lysate (B).

Fibronectin (568) - sc-52331 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fibronectin (568): sc-52331. Western blot analysis of Fibronectin expression in Hep G2 (A) and HT-1080 (B) whole cell lysates.

Fibronectin (2755-8) - sc-69681 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fibronectin (2755-8): sc-69681. Western blot analysis of Fibronectin expression in human platelet extract (A) and Caki-1 whole cell lysate (B).

Anti-Fibronectin antibody - ab23750 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab23750 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab23750, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Fibronectin antibody - ab23751 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab23751 at 1/200 dilution staining pig fibroblast cells by ICC/IF. The cells were paraformaldehyde fixed and blocked with serum prior to incubation with antibody for 8 hours at 4°C. An Alexa-Fluor ® 488 conjugated  donkey anti-rabbit antibody was used as the secondary. The image was taken using a confocal laser scanning microscope and shows the presence of abundant fibronectin (green) in the pig fibroblasts. DAPI was used as nuclear counterstain (Blue).See Abreview

Anti-Fibronectin antibody - ab299 from Abcam

Prices $391.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of Fibronectin antibody staining in Human breast adenocarcinoma formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab299, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Fibronectin antibody - ab183352 from Abcam

Prices $384.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human renal cancer tissue labeling Fibronectin with ab183352 at 1/400 dilution.

Anti-Fibronectin antibody - ab61214 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Fibronectin antibody (ab61214) at 1/500 dilutionLane 1 : extracts from HeLa cellsLane 2 : extracts from HeLa cells with immunizing peptide

Anti-Fibronectin antibody [2F12] - ab25583 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F12
Anti-Fibronectin antibody [2F12] (ab25583) at 1/2000 dilution + TE 671 (Human Rhabdomyosarcoma) Whole Cell Lysate at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-Fibronectin antibody [568], prediluted - ab51836 from Abcam

Prices $370.00
Sizes 5 ml
Host Mouse
Clonality Monoclonal
Clone 568
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