EPAS1

Gene Symbol	EPAS1
Entrez Gene	2034
Alt Symbol	ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73
Species	Human
Gene Type	protein-coding
Description	endothelial PAS domain protein 1
Other Description	EPAS-1|HIF-1-alpha-like factor|HIF-1alpha-like factor|HIF-2-alpha|HIF2-alpha|PAS domain-containing protein 2|basic-helix-loop-helix-PAS protein MOP2|class E basic helix-loop-helix protein 73|endothelial PAS domain-containing protein 1|hypoxia-inducible factor 2 alpha|hypoxia-inducible factor 2-alpha|member of PAS protein 2
Swissprots	Q99630 Q86VA2 Q99814
Accessions	AAX93237 AAY14704 EAX00255 Q99814 AF052094 AK123845 BAG53969 BC015869 BC051338 AAH51338 BM671511 CD109908 U51626 AAC51212 U81984 AAB41495 XM_011532698 XP_011531000 NM_001430 NP_001421
Function	Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
Subcellular Location	Nucleus {ECO:0000250|UniProtKB:P97481, ECO:0000255|PROSITE-ProRule:PRU00981}. Nucleus speckle {ECO:0000250|UniProtKB:P97481}. Note=Colocalizes with HIF3A in the nucleus and speckles. {ECO:0000250|UniProtKB:P97481}.
Tissue Specificity	Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells.
Top Pathways	Renal cell carcinoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse HIF2A / EPAS1 ELISA Kit (Sandwich ELISA) - LS-F6739 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Human HIF2A / EPAS1 ELISA Kit (Sandwich ELISA) - LS-F6738 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Rat HIF2A / EPAS1 ELISA Kit (Sandwich ELISA) - LS-F9117 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 78 pg/ml Range 0.156-10 ng/ml

Human/Rat Total HIF-2 alpha/EPAS1 DuoSet IC ELISA - DYC2997-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates)

Human/Rat Total HIF-2 alpha/EPAS1 DuoSet IC, 5 Plate - DYC2997-5 from R&D Systems Category ELISA Kit

Human HIF2a ELISA Kit - abx151810 from Abbexa Category ELISA Kit Sensitivity 0.062 ng/ml Range 0.156 ng/ml - 10 ng/ml

Endothelial PAS domain-containing protein 1, EPAS1, Human, ELISA Kit - E2004h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Hypoxia Inducible Factor 2 Alpha (HIF2a), Human, ELISA Kit - SED466Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.054ng/mL Range 0.156-10ng/mL

Hypoxia-inducible factor 2 (HIF-2), Human, ELISA Kit - CSB-E12113h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 15.6 pg/ml Range 62.5 pg/ml-4000 pg/ml

endothelial PAS domain protein 1, ELISA Kit - MBS282374 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

endothelial PAS domain protein 1, ELISA Kit - MBS702348 from MyBioSource Category ELISA Kit Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 15.6 pg/ml. Range 62.5 pg/ml-4000 pg/ml.

ELISA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) - SED466Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.057ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) - SED466Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.064ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) - SED466Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 30pg/mL. Range 78.13-5000pg/mL The standard curve concentrations used for the ELISA’s were 5000pg/mL, 2500pg/mL, 1250pg/mL, 625pg/mL, 312.5pg/mL, 156.25pg/mL, 78.13pg/mL

Human hypoxia-inducible factor 2(HIF-2) ELISA kit - CSB-E12113h from Cusabio Category ELISA Kit Sensitivity 15.6 pg/ml Range 62.5 pg/ml-4000 pg/ml

ELISA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) - SED466Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.057ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Rat HIF2A / EPAS1 ELISA Kit (Custom ELISA) - LS-F19021 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse HIF2A / EPAS1 ELISA Kit (Sandwich ELISA) - LS-F19020 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 0.156-10 ng/ml

Human HIF2A / EPAS1 ELISA Kit (Sandwich ELISA) - LS-F13165 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Hypoxia Inducible Factor 2 Alpha (HIF2a), Human, ELISA Kit - DL-HIF2a-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human HIF2a ELISA Kit - orb368184 from Biorbyt Category ELISA Kit Prices $553.00, $621.00 Sizes 48 test, 96 test Range Detection Range: 0.156-10ng/mL Detection low threshold: 0.053ng/mL

EPAS1 - EKH4082 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

EPAS1 ELISA Kit (Human) : 96 Wells (OKEH01424) - OKEH01424 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.078 ng/mL Range 0.156 - 10 ng/mL

Human EPAS1 ELISA Kit - E013092 from Biobool Category ELISA Kit Sensitivity 15.6 pg/ml

Human HIF2a ELISA Kit - E019186 from Biobool Category ELISA Kit Sensitivity Typically less than 0.057ng/mL.

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