EPAS1
| Gene Symbol | EPAS1 |
|---|---|
| Entrez Gene | 2034 |
| Alt Symbol | ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73 |
| Species | Human |
| Gene Type | protein-coding |
| Description | endothelial PAS domain protein 1 |
| Other Description | EPAS-1|HIF-1-alpha-like factor|HIF-1alpha-like factor|HIF-2-alpha|HIF2-alpha|PAS domain-containing protein 2|basic-helix-loop-helix-PAS protein MOP2|class E basic helix-loop-helix protein 73|endothelial PAS domain-containing protein 1|hypoxia-inducible factor 2 alpha|hypoxia-inducible factor 2-alpha|member of PAS protein 2 |
| Swissprots | Q99630 Q86VA2 Q99814 |
| Accessions | AAX93237 AAY14704 EAX00255 Q99814 AF052094 AK123845 BAG53969 BC015869 BC051338 AAH51338 BM671511 CD109908 U51626 AAC51212 U81984 AAB41495 XM_011532698 XP_011531000 NM_001430 NP_001421 |
| Function | Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD. |
| Subcellular Location | Nucleus {ECO:0000250|UniProtKB:P97481, ECO:0000255|PROSITE-ProRule:PRU00981}. Nucleus speckle {ECO:0000250|UniProtKB:P97481}. Note=Colocalizes with HIF3A in the nucleus and speckles. {ECO:0000250|UniProtKB:P97481}. |
| Tissue Specificity | Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells. |
| Top Pathways | Renal cell carcinoma |
Human HIF-2-alpha full length protein - ab131743 from Abcam
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Human HIF-2-alpha protein fragment - ab114171 from Abcam
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Mouse HIF-2-alpha peptide - ab21447 from Abcam
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HIF2A / EPAS1 Antibody Blocking Peptide - LS-E427 from LifeSpan Bioscience
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HIF2A / EPAS1 Antibody Blocking Peptide - LS-E3055 from LifeSpan Bioscience
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HIF2A / EPAS1 Antibody Blocking Peptide - LS-E11270 from LifeSpan Bioscience
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Recombinant Human HIF-2 alpha/EPAS1 Protein - H00002034-P03 from Novus Biologicals
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EPAS1-Antibody-N-term-Blocking-peptide - BP10707a from Abgent, a WuXi AppTec company
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EPAS1-Antibody-C-term-Blocking-Peptide - BP14190b from Abgent, a WuXi AppTec company
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Human HIF2a Protein - abx067165 from Abbexa
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HIF2A / HIF2 alpha - H00002034-P03 from Acris Antibodies
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HIF2A / HIF2 alpha - H00002034-P03-10 from Acris Antibodies
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HIF2A / HIF2 alpha - H00002034-P03-25 from Acris Antibodies
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HIF2A / HIF2 alpha - H00002034-Q01-10 from Acris Antibodies
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HIF2A / HIF2 alpha - H00002034-Q01-25 from Acris Antibodies
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Hypoxia Inducible Factor 2 Alpha (HIF2a), Human - 20-8800 from ARP American Research Products
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EPAS1 fusion protein - Ag15199 from Proteintech Group
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Recombinant Human EPAS1 - EPAS1-29318TH from Creative Biomart
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Recombinant Human EPAS1, GST-tagged - EPAS1-12475H from Creative Biomart
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Recombinant Hypoxia Inducible Factor 2 Alpha (HIF2a) - RPD466Hu01 from Uscn Life Science Inc.
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Recombinant Hypoxia Inducible Factor 2 Alpha (HIF2a) - RPD466Mu01 from Uscn Life Science Inc.
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Recombinant Hypoxia Inducible Factor 2 Alpha (HIF2a) - RPD466Mu02 from Uscn Life Science Inc.
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Recombinant Hypoxia Inducible Factor 2 Alpha (HIF2a) - RPD466Ra01 from Uscn Life Science Inc.
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Recombinant Hypoxia Inducible Factor 2 Alpha (HIF2a) - RPD466Hu01 from Cloud-clone
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Recombinant Human Endothelial PAS domain-containing protein 1(EPAS1) ,partial - CSB-YP860780HU CSB-EP860780HU CSB-BP860780HU CSB-MP860780HU from Cusabio
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