Gene Symbol | Reg3b |
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Entrez Gene | 18489 |
Alt Symbol | HIP, PAP1, Pap, REG-III |
Species | Mouse |
Gene Type | protein-coding |
Description | regenerating islet-derived 3 beta |
Other Description | REG-3-beta|RegIII (beta)|pancreatitis-associated protein 1|reg III-beta|regenerating islet-derived protein 3-beta|regenerating islet-derived protein III-beta |
Swissprots | P35230 |
Accessions | BAA18929 EDK99014 P35230 BC027525 AAH27525 D13509 BAA02727 D63359 BAA18928 NM_011036 NP_035166 |
Function | Bactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues. {ECO:0000269|PubMed:21694778, ECO:0000269|PubMed:22252863}. |
Subcellular Location | Secreted. Note=Found in the apical region of pancreatic acinar cells. {ECO:0000250}. |
Tissue Specificity | Constitutively expressed in the small intestine, moderately in colon and at an extremely low level in healthy pancreas. |
Reg IIIβ siRNA (m) - sc-155961 from Santa Cruz Biotechnology
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Reg IIIβ shRNA Plasmid (m) - sc-155961-SH from Santa Cruz Biotechnology
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Reg IIIβ shRNA (m) Lentiviral Particles - sc-155961-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN40067 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND40067 from Sigma-Aldrich
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REG3B siRNA (Mouse) - CRM2951 from Cohesion Biosciences
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REG3B - MBS8207679 from MyBioSource
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shRNA set against Mouse Reg3b (NM_011036.1) - SHH391752 from Creative biogene
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shRNA set against Mouse Pap(NM_011036.1) - SHR175308 from Creative biogene
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Mouse REG3B siRNA - orb282427 from Biorbyt
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REG3B shRNA Plasmid (Mouse) - CHM2951 from Cohesion Biosciences
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REG3B miRNA 3'UTR clone - MiUTR1M-08885 from Creative biogene
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