| Gene Symbol |
Fbxw7
|
| Entrez Gene |
50754
|
| Alt Symbol |
1110001A17Rik, AGO, Cdc4, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, SEL-10
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
F-box and WD-40 domain protein 7
|
| Other Description |
F-box and WD-40 domain protein 7, archipelago homolog|F-box and WD-40 domain-containing protein 7|F-box protein FBW7|F-box protein Fbxw6|F-box-WD40 repeat protein 6|F-box/WD repeat-containing protein 7|f-box only protein 30
|
| Swissprots |
A2RRI5 Q8VHP4 Q8CCS5 Q8VBV4
|
| Accessions |
AAL40930 EDL15399 EDL15400 Q8VBV4 AB221593 AF391192 AAL40928 AF427101 AAL50052 AK003200 AK032174 BAC27743 BC060620 BC065380 BC066093 BC085184 AAH85184 BC131648 AAI31649 XM_006501656 XP_006501719 XM_006501657 XP_006501720 XM_006501658 XP_006501721 NM_001177773 NP_001171244 NM_001177774 NP_001171245 NM_080428 NP_536353
|
| Function |
Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation. {ECO:0000250|UniProtKB:Q969H0}.
|
| Subcellular Location |
Nucleus, nucleoplasm {ECO:0000269|PubMed:11461910}.
|
| Tissue Specificity |
Widely expressed with highest levels in brain, heart and testis. {ECO:0000269|PubMed:11735228}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|
