Fbxw7

Gene Symbol Fbxw7
Entrez Gene 50754
Alt Symbol 1110001A17Rik, AGO, Cdc4, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, SEL-10
Species Mouse
Gene Type protein-coding
Description F-box and WD-40 domain protein 7
Other Description F-box and WD-40 domain protein 7, archipelago homolog|F-box and WD-40 domain-containing protein 7|F-box protein FBW7|F-box protein Fbxw6|F-box-WD40 repeat protein 6|F-box/WD repeat-containing protein 7|f-box only protein 30
Swissprots A2RRI5 Q8VHP4 Q8CCS5 Q8VBV4
Accessions AAL40930 EDL15399 EDL15400 Q8VBV4 AB221593 AF391192 AAL40928 AF427101 AAL50052 AK003200 AK032174 BAC27743 BC060620 BC065380 BC066093 BC085184 AAH85184 BC131648 AAI31649 XM_006501656 XP_006501719 XM_006501657 XP_006501720 XM_006501658 XP_006501721 NM_001177773 NP_001171244 NM_001177774 NP_001171245 NM_080428 NP_536353
Function Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation. {ECO:0000250|UniProtKB:Q969H0}.
Subcellular Location Nucleus, nucleoplasm {ECO:0000269|PubMed:11461910}.
Tissue Specificity Widely expressed with highest levels in brain, heart and testis. {ECO:0000269|PubMed:11735228}.
Top Pathways Ubiquitin mediated proteolysis

Cdc4 CRISPR/Cas9 KO Plasmid (m) - sc-424472 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Cdc4 HDR Plasmid (m) - sc-424472-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Cdc4 Double Nickase Plasmid (m) - sc-424472-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Cdc4 Double Nickase Plasmid (m2) - sc-424472-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Cdc4 CRISPR Activation Plasmid (m) - sc-424472-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Cdc4 CRISPR Activation Plasmid (m2) - sc-424472-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Cdc4 Lentiviral Activation Particles (m) - sc-424472-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Cdc4 Lentiviral Activation Particles (m2) - sc-424472-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Cdc4 siRNA (m) - sc-37548 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Cdc4 shRNA Plasmid (m) - sc-37548-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Cdc4 shRNA (m) Lentiviral Particles - sc-37548-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU005041 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN31284 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31284 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FBXW7 siRNA (Mouse) - CRM5126 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

FBXW7 - MBS8234176 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

Mouse FBXW7 siRNA - orb284602 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

FBXW7 shRNA Plasmid (Mouse) - CHM5126 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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