Fbxw7

Gene Symbol Fbxw7
Entrez Gene 50754
Alt Symbol 1110001A17Rik, AGO, Cdc4, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, SEL-10
Species Mouse
Gene Type protein-coding
Description F-box and WD-40 domain protein 7
Other Description F-box and WD-40 domain protein 7, archipelago homolog|F-box and WD-40 domain-containing protein 7|F-box protein FBW7|F-box protein Fbxw6|F-box-WD40 repeat protein 6|F-box/WD repeat-containing protein 7|f-box only protein 30
Swissprots A2RRI5 Q8VHP4 Q8CCS5 Q8VBV4
Accessions AAL40930 EDL15399 EDL15400 Q8VBV4 AB221593 AF391192 AAL40928 AF427101 AAL50052 AK003200 AK032174 BAC27743 BC060620 BC065380 BC066093 BC085184 AAH85184 BC131648 AAI31649 XM_006501656 XP_006501719 XM_006501657 XP_006501720 XM_006501658 XP_006501721 NM_001177773 NP_001171244 NM_001177774 NP_001171245 NM_080428 NP_536353
Function Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation. {ECO:0000250|UniProtKB:Q969H0}.
Subcellular Location Nucleus, nucleoplasm {ECO:0000269|PubMed:11461910}.
Tissue Specificity Widely expressed with highest levels in brain, heart and testis. {ECO:0000269|PubMed:11735228}.
Top Pathways Ubiquitin mediated proteolysis

Recombinant F-Box And WD Repeat Domain Containing Protein 7 (FBXW7) - RPJ890Mu01 from Cloud-clone

Category Protein
Source E.coli
Species Mouse

Recombinant Mouse F-box/WD repeat-containing protein 7(Fbxw7) - CSB-YP851809MO CSB-EP851809MO CSB-BP851809MO CSB-MP851809MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

F-box/WD repeat-containing protein 7 (Fbxw7), Recombinant Protein - MBS1430571 from MyBioSource

Category Protein
Prices $1,425.00, $1,425.00, $1,655.00, $1,655.00, $2,410.00, $2,410.00, $2,855.00, $2,855.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse

FBXW7 Recombinant Protein (OPCD03138) - OPCD03138 from Aviva Systems Biology

Category Protein
Source E.coli
Species Mouse
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