XRCC5

Gene Symbol XRCC5
Entrez Gene 7520
Alt Symbol KARP-1, KARP1, KU80, KUB2, Ku86, NFIV
Species Human
Gene Type protein-coding
Description X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Other Description 86 kDa subunit of Ku antigen|ATP-dependent DNA helicase 2 subunit 2|ATP-dependent DNA helicase II 80 kDa subunit|CTC box-binding factor 85 kDa subunit|CTC85|CTCBF|DNA repair protein XRCC5|Ku autoantigen, 80kDa|Ku86 autoantigen related protein 1|TLAA|X-ray repair cross-complementing protein 5|lupus Ku autoantigen protein p86|nuclear factor IV|thyroid-lupus autoantigen
Swissprots Q9UCQ0 Q4VBQ5 A8K3X5 Q9UCQ1 P13010 Q53HH7 Q7M4N0 Q0Z7V0
Accessions AAC52087 AAD14875 AAY14659 AAY24231 ABG46942 CBX87168 EAW70562 EAW70563 P13010 AK026166 AK096408 AK222603 BAD96323 AK290740 BAF83429 BC019027 AAH19027 BC095442 AAH95442 BG717693 BP375944 BU184024 DQ892660 ABM83586 DQ895925 ABM86851 J04977 AAA59475 M30938 AAA36154 X57500 CAA40736 NM_021141 NP_066964
Function Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. The XRCC5/6 dimer probably also acts as a 5'- deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-el
Subcellular Location Nucleus. Nucleus, nucleolus. Chromosome.
Top Pathways Non-homologous end-joining

Human XRCC5 gene - orb91741 from Biorbyt

Prices $255.00
Sizes 10 μg
Species Human

Human-XRCC5-cDNA-Clone - DC04783 from Abgent, a WuXi AppTec company

Prices $989.55
Sizes 10 µg
Species Human
Accession BC019027

XRCC5 - MBS1269493 from MyBioSource

Species Human
Accession BC019027

Human XRCC5 ORF clone(NM_021141.3) - CDCL186794 from Creative Biomart

Species Human
Accession NM_021141.3

Human XRCC5 ORF Clone(NM_021141.3) - CDCL181449 from Creative Biomart

Species Human
Accession NM_021141.3

human XRCC5 ORF clone - CDCH101880 from Creative Biomart

Species Human
Accession NM_021141

human XRCC5 ORF clone - CDCH101881 from Creative Biomart

Species Human
Accession NM_021141

Human XRCC5 ORF clone(NM_021141.3) - CDCL186794 from Creative biogene

Species Human

Human XRCC5 ORF Clone (BC019027) - CDCS415294 from Creative biogene

Species Human
Accession P13010
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