XRCC5

Gene Symbol	XRCC5
Entrez Gene	7520
Alt Symbol	KARP-1, KARP1, KU80, KUB2, Ku86, NFIV
Species	Human
Gene Type	protein-coding
Description	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Other Description	86 kDa subunit of Ku antigen|ATP-dependent DNA helicase 2 subunit 2|ATP-dependent DNA helicase II 80 kDa subunit|CTC box-binding factor 85 kDa subunit|CTC85|CTCBF|DNA repair protein XRCC5|Ku autoantigen, 80kDa|Ku86 autoantigen related protein 1|TLAA|X-ray repair cross-complementing protein 5|lupus Ku autoantigen protein p86|nuclear factor IV|thyroid-lupus autoantigen
Swissprots	Q9UCQ0 Q4VBQ5 A8K3X5 Q9UCQ1 P13010 Q53HH7 Q7M4N0 Q0Z7V0
Accessions	AAC52087 AAD14875 AAY14659 AAY24231 ABG46942 CBX87168 EAW70562 EAW70563 P13010 AK026166 AK096408 AK222603 BAD96323 AK290740 BAF83429 BC019027 AAH19027 BC095442 AAH95442 BG717693 BP375944 BU184024 DQ892660 ABM83586 DQ895925 ABM86851 J04977 AAA59475 M30938 AAA36154 X57500 CAA40736 NM_021141 NP_066964
Function	Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. The XRCC5/6 dimer probably also acts as a 5'- deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-el
Subcellular Location	Nucleus. Nucleus, nucleolus. Chromosome.
Top Pathways	Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Ku80 full length protein - ab132946 from Abcam Category Protein Source Wheat germ Species Human

Human Ku80 peptide - ab99167 from Abcam Category Peptide

Human Ku80 peptide - ab48059 from Abcam Category Peptide Species Human

XRCC5 / Ku80 Antibody Blocking Peptide - LS-E12063 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XRCC5 / Ku80 Antibody Blocking Peptide - LS-E26077 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Ku80/XRCC5 Protein - H00007520-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Ku80/XRCC5 Blocking Peptide - NB100-508PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg

XRCC5-Antibody-Center-K439-Blocking-peptide - BP11960c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Ku80 blocking peptide - GTX89363-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Human XRCC5 His tag protein - orb84624 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 20 μg, 50 μg Source Insect Species Human

Goat anti XRCC5 antibody Immunizing peptide - orb16883 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

XRCC5 peptide - orb218102 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg

XRCC5 Blocking Peptide - 33R-3345 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Ku80 Blocking Peptide - abx063433 from Abbexa Category Peptide Species Human, Monkey

Ku80 Blocking Peptide - abx063434 from Abbexa Category Peptide Species Human, Monkey

Ku80 Blocking Peptide - abx063432 from Abbexa Category Peptide Species Human, Monkey

Ku80 Peptide - AC21-0905-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

XRCC5 / Ku80 / Ku86 - H00007520-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

XRCC5 / Ku80 / Ku86 - H00007520-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

XRCC5 Peptide - 45-173P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

XRCC5 fusion protein - Ag9454 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

XRCC5 fusion protein - Ag9512 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human XRCC5 protein, His-tagged - XRCC5-149H from Creative Biomart Category Protein Source Insect cells Species Human

Recombinant Human XRCC5, His tagged - XRCC5-1798H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human XRCC5, His-tagged - XRCC5-29197TH from Creative Biomart Category Protein Source E. coli Species Human

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